Narrative In my early 40s I began to have more difficulty concentrating, and I remember feeling unusually forgetful. For a while, I ignored these symptoms until I started to uncontrollably twitch and make fidgety motions. When the chorea started, it was clear to my doctor that I was dealing with something more than just forgetfulness. The fact that my mom also suffered from the disease confirmed the doctor’s predictions, and that is when I was diagnosed with Huntington’s Disease. From...
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Introduction of Huntington’s disease Huntington’s disease (HD) is a severe neurodegenerative disorder that is inherited in an autosomal dominant manner. HD progresses in mid-life showing motor and cognitive function impairments, and psychiatric deficiencies. It is caused by a mutation of the Huntingtin gene creating a CAG-elongation at the amino-terminus of the Huntingtin protein (HTT)1. Having more repeats has been previously associated with the earlier onset of the disease2. The mutated protein forms toxic aggregates in the brain, causing neural death...
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There are many diseases out in the world that are affecting people’s lives in different ways. They can either be an infectious or a non-infectious disease. A non- infectious disease would be Huntington’s disease which is inherited. It causes a severe breakdown of nerve cells of the brain. The parts of the brain that get damage are the basal ganglia, cerebral cortex the frontal and temporal lobes, ventricles, and caudate nuclei. This disease is most frequently found in people with...
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Huntington’s disease is a genetic disease that causes progressive damage to cells in the basal ganglia and cerebral cortex which are both found in the brain. These areas control movement and the way one thinks, understands and remembers. The disease was characterized by George Huntington in 1872. People with Huntington’s disease generally develop symptoms between the ages of 30 and 50. These symptoms include: Cognitive: amnesia, delusion, lack of concentration, memory loss, mental confusion, difficulty thinking and understanding. Muscular: abnormality...
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Introduction Behavior is commonly characterized as a response to stimuli, regardless of whether internal or external, that changes an organism’s response to its habitat. Animals run, stay still, or counterstrike to predators; in response to external and internal stimuli birds construct complex and distinguished nests; plants show positive phototropism; and humans behave in both simple and complex ways depending on their keenness and culture. Behavior depends on the expression of the genotype of an organism, which takes happens inside a...
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Introduction Three of the world’s most concerning psychological disorders are Huntington’s disease, schizophrenia, and dissociative identity disorder (DID). Over ten million adults in the United States are affected by a severe mental illness. The difficulty people must face to cope with the effects along with the recovery of one of these diseases is a constant battle. Today, the concept of recovery for these patients is a determined mindset with international concord. The notion of recovery is “a commitment to the...
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Huntington’s disease is an inherited brain disorder that is caused when specific cells in the brain die. This leads to loss of cognitive function, loss of walking, eating and swallowing and eventually death. Symptoms typically start between 30-50-year old Huntington’s disease is extremely rare and affects one in every 10,000 people. Huntington’s disease is caused by a mutation of the HTT gene, everyone has a copy of the HTT gene but only those with the mutation may have the possibility...
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Huntington’s is a disease in the brain, Huntington’s disease affects the Neurological and nervous system. Huntington’s disease is passed on from generation to generation through an altered gene from your parents. Huntington’s causes the death of brain cells in parts of the brain causing slow loss of cognitive ability, physical and emotional functions. Huntington’s disease is a serious and debilitating disease for which there is currently no cure. The most noticeable symptom of Huntington’s disease is jerky movements that is...
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Human Genetics and Genomics- Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington’s Disease Mice Huntington`s Disease (HD) is an autosomal dominant neurodegenerative disease affecting 4-to-7 per 100,000 individuals. It is classed as a trinucleotide repeat disorder (Marcy et al, 1993) due to the fact that it results from an expanded CAG repeat which leads to a polyglutamine strand of variable length at the N-terminus (Walker, 2007). The normal number of CAG repeats is 10-35 times, however,...
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Rationale “Congenital diseases are disorders that are present before or at birth.” (spine-health, 2019) “Huntington’s disease is a hereditary disease that is more common in European descent.” (ghr, 2019) It will usually affect hosts at the ages between 30-40, but there are cases of juvenile Huntington’s disease and late-onset. ‘Huntington’s disease causes the breakdown of nerve cells in the brain’ (mayoclinic, 2019) “A Pedigree is a diagram that depicts the biological relationships between an organism and its ancestors.” (biologydictionary, 2019)...
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