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What Causes Extreme Weakness And Tiredness?

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It is normal to feel weak and tired after executing some strenuous activities either at home or in the office. Weakness, tiredness or exhaustion can occur when you have flu, cold, or a viral infection. But it is considered abnormal if you perpetually experience extreme weakness and tiredness. It may require you to confer with your doctor.

Extreme weakness is a form of lasting fatigue; it is a protracted form of exhaustion. Extreme weakness and tiredness is an unexplained and persistent tiredness. Extreme weakness is similar to the feeling you get when you come down with the flu or when you have insufficient sleep.

Extreme weakness and tiredness is similar to symptoms experienced when you have chronic fat, or systemic exertion intolerance disease (SEID). When you are very weak and exhausted extremely, you may be incapable of being productive at the home front. In this article, we examined the possible causes of extreme weakness and tiredness and possible ways you can overcome them.

So, what causes extreme exhaustion? Extreme weakness and tiredness may be caused by some possible factors such as:

  • Anemia
  • Depression
  • Allergic rhinitis
  • Fibromyalgia
  • COPD
  • Liver disease
  • Chronic kidney disease


If the cause of your extreme weakness and tiredness is as a result of anemia, you may experience symptoms like cold, dizziness, and irritability.

Anemia occurs when you have insufficient red blood cells, triggered by blood loss or low production of red blood cells. Anemia is caused by hemorrhoids or gastrointestinal problems like ulcer. Gastrointestinal issues can be caused by the intake of NSAIDs including aspirin and ibuprofen.

Your doctor may perform a blood test to establish the cause of your anemia and administer the right treatment.


The symptoms of extreme weakness and tiredness caused by depression may include a feeling of sadness, hopelessness, worthlessness, helplessness, and fatigue.

Extreme weakness and tiredness may be caused by anxiety and depression and women are more prone to developing this condition. It can also be hereditary and runs in families.

Depression can make you to be in an unhappy and miserable mood all through the day. Depression can cause you to sleep excessively or sleep insufficiently, overindulge or eat too little.

If depression is the cause of your extreme tiredness and weakness, check with your doctor for proper examination. In some cases, there may be no known cause for depression. In this case, your doctor may recommend drugs to help relieve your symptoms or may refer you to a psychologist.

Allergic rhinitis

Symptoms: Fatigue, headache, itchiness, nasal congestion, and drainage Allergic rhinitis is a common cause of extreme fatigue and tiredness. However, allergic rhinitis can be treated. If your extreme exhaustion is caused by allergic rhinitis, you may experience symptoms like nasal congestion, fatigue, itchiness, and headache.

Your doctor may ask you questions about your symptoms and medical history in a bid to diagnose your condition. Your doctor will find out what triggers your allergies, be it insects, animal dander, weather changes, mildew, and others.

To reduce allergic rhinitis symptoms, you have to avoid making contact with the allergen. There are medications that may be prescribed by your doctor to help relieve symptoms. Some medications that may help include:

  • Nasal steroids
  • Oral antihistamines
  • Nasal antihistamines
  • Leukotriene modifiers
  • Mast cell stabilizers


Symptoms: Chronic fatigue, deep muscle pain, painful tender points, sleep problems, anxiety, depression. Fibromyalgia is also among the causes of extreme fatigue. Fibromyalgia and chronic fatigue syndrome are two dissimilar but related conditions since they have similar symptoms.

Fibromyalgia makes you sleep for long hours yet still feel tired and not rested properly. The condition causes you to feel very tired all through the day. Your sleep may be interrupted by numerous waking, but you may be unable to recall any sleep disruptions the next day. You may be unable to exercise regularly with fatigue and fibromyalgia, making you susceptible to mood-related problems.

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If fibromyalgia is responsible for your extreme fatigue, you may experience symptoms like:

  • Sleep problems
  • Anxiety
  • Depression
  • Deep muscle pain
  • Chronic Fatigue

Regular exercises help to improve mood, sleep and fatigue. You can try engaging in moderate exercises like swimming to overcome fatigue. It is advisable to begin slowing and then increase the intensity gradually because overdoing any form of exercise may deteriorate your condition.

Food Allergies and Food Intolerance

Symptoms: Fatigue, sleepy, continually exhausted. Food allergies and intolerances can cause you to lose energy, thereby leading to fatigue, weakness and exhaustion. In some cases, fatigue and exhaustion may point to food allergy or intolerance. Celiac disease (difficulty in digesting gluten), may also cause exhaustion.

If food allergies are causing you extreme weakness and tiredness, you may experience symptoms like sleepiness, exhaustion, and fatigue. Consult your doctor about the elimination diet. Also, you may undergo food allergy test to help detect the wrong foods.

Rheumatoid Arthritis and Fatigue

Extreme fatigue caused by rheumatoid arthritis may cause you to experience symptoms like joint inflammation, fatigue, morning stiffness, and joint pain.

Rheumatoid arthritis (RA), is an inflammatory arthritis, is caused by excessive fatigue. This is due to the fact that joint damage can lead to disability.

RA can best be addressed with aggressive treatment. Also, there are some medications you can use in early RA treatment, they include:

  • nonsteroidal anti-inflammatory drugs (NSAIDs)
  • disease-modifying antirheumatic drugs (DMARDs)

Apart from rheumatoid arthritis, autoimmune disorders like lupus and Sjogren’s disease, can also lead to fatigue.

Sleep Apnea

Sleep apnea is another major cause of extreme weakness and tiredness. Symptoms may include chronic fatigue, tiredness upon awakening, and snoring.

Snoring linked with periods when breathing stops is known as sleep apnea. This may lead to daytime sleepiness and excessive fatigue.

Confer with your doctor about a sleep study to establish if you have sleep apnea. Sleep apnea is mostly common among the obese or overweight people. So try to lose weight and stop smoking.

It may require you to wear a device called CPAP, that aids open your airways when you sleep.

Surgery will be used to remove tissues forming blockages in the airways in severe cases. Sleep apnea may lead to heart attack or stroke if left untreated.

Heart Disease and Fatigue

If your fatigue is caused by heart-related disease, you may experience extreme tiredness with an activity that used to be easy. There are prescribed drugs that can help reduce the exhaustion, and bring back your energy.


Extreme weakness and tiredness caused by diabetes may cause you to experience symptoms like increased hunger, increased thirst, increased urination, extreme fatigue, and unusual weight loss.

To treat type 2 diabetes, your doctor may recommend:

  • engage in regular exercises
  • maintain normal blood glucose control
  • taking diabetes drugs (insulin or other drugs)
  • eating a low glycemic index carbohydrate
  • losing surplus weight

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What Causes Extreme Weakness And Tiredness? (2022, February 17). Edubirdie. Retrieved November 27, 2022, from
“What Causes Extreme Weakness And Tiredness?” Edubirdie, 17 Feb. 2022,
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What Causes Extreme Weakness And Tiredness? [Internet] Edubirdie. 2022 Feb 17 [cited 2022 Nov 27]. Available from:
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