University:
Boston University
Course:
GMS AN 708 | Clinical Anatomy
Academic year:

2022
Views:

231

Pages:

34
Author:

SpaceCadet101

Vitamins Essential organic substance required in ung or Mgn Not for body Structure. Prevent disease The first discoverd Vital amine is "Thiamine" "VH B Nitamins Coenzymes "Water Soluble" Single dose intake Fat Soluble Vitamins" Vitamin C Lascarician" . Vit AKED" • Vitamin B complex Absorbed by bile Salts BBB Bia •Transported by Carrier proteins Stored in Liver, Muscle. •Transported freely in Blood adipose Tisine Not Stored excreted •Not excreted Slawely in bile" Toricity Hypervitaminosis" in urine No toxicity uit AE K •Rapid deficiency require daily doses Bile sautsymph Vit A Protelb Vitamin A Retinoids Anti night blin dness Retinol Diet Storage from Liver 2 eye Retinal Irrevesible Oridution optic Nerve Brain # Light Con Cells Day Vision Rods night vision "Vitamin A" Retinoic acid Skin "Horment bind to receptar" Regulate Epithelia growth of Skin curd mucus membrane Retina Keratin Epithelia Sources of Vit A Plant Sources "B- Coratene found in Corrot Pumpkins. Sweet Potato Green vegetables Animal Sources "Retinyl ester" found in Liver mith butter egg yolk Functions of Retinoids Ca Bone HG Night Vision "Dia Light" ADK 12) Growth of bone, & eeth in children 151 Cellular maturation anel Differentiation kem. of epithelial Cells of Shin mucus membrane Reproductive spermatogenesis in male 15 Prevent fetal resorption in female Antioxidant E>C>A ↑ immunity Treatment of Skin disease • 13 cis retinoic acid "Isotretinoin' Treatment of acne • All trans retinoic acid "Tretinoin Treatment of psoria sis #Vitamin A Deficiency. Night blinduess Nyctalopia Early sign •Difficult to see in dim Light • may cause irreversible eye damage later Dry eye Curnee xero phthalmia sever defidensy Bitot's spots Conjunctivitis. Fiscuring of cornea 15) Dry skin. Keratinzation seero dermo Repeated cough due to loss of respiratory tract resistance. #Hyper Vitaminosis Toxicity Not from B. Caroteane because of regulatry absortion From animal or performed Vit A supplemet 13) 80% of uit A is stored in Liver Dry preritic skin curly sigh ✓ Enlarged cirrhotic Liver Retinol ✓ intra Cranial pressure headch. ✓ Fetal malformation. Digestion absorption. Storage. Listribution of vit A Plut B-Carotene lymphatic system Lipid Transport 2 Retinal protein Refind Retinol Absorption ester fudy acid Lipoprotein Retinal Palmitic acid Fatty deit Yetlund ster Liver Sturmge Retluol RBP retinol binding Protein Distribution RBP Chylomicron popen Reseptor uptake Eyr Shin Visual Cycle "Wald cycle": Gigier "nervei impulse" optic were opsin protein Brain "Occipital Cortex Cata "Liver All traus retinal 15 Cis retinal Rhodopsin Visual pigment" Dim Light Dark vision Rod cell of retina Recycling in Liver All trans retinal reditume All trans retinal, isomerase 11 as Velinol 11 Cis retocal Vitamin D Sunshine vitamin. Ergo sterol Sunlight Ergo Calciferol Vit Da mushroom 7 Dehydro cholesterol Sunlight Chole calciferol Vit D3 • vitamin D is asteroid hormone thet ↑serum Calcium and Phosphate. * Functions of vit D:- Bleeck Cat po absorption at intestine città 15 cổ, pou reabsorption at Kiduy Demeniralet chof Kiduy ↑ cử, pải mobilization from bone «Bone resorptions, Po osteoclayca Pou vit urive *Activation of Vitamin Dis 2 sequential nydroxylations (ot) Chole calciferol C27 Livet SER "Micosoma 25 ingdroxylase Cytochrome Puso "Iyon 25 hydrong chale calciferol Calcidiol Storage form Liver Staraye Inactive forw Leval ave Hormat Storage form 25/OH CCF PTH • Vit. D. binding protein Blood mitochondria 1.25 Di hydroxy cef Calcitriol «Active form ✓ Kidney Activation 25 hy dresey.cif Calcidiol