University:
Boston University
Course:
ENG ME 302 | Engineering Mechanics II
Academic year:

2022
Views:

44

Pages:

18
Author:

SpaceCadet101

CELL-MET ERC: Vision & Strategic Planning Heart Disease -Americans suﬀer one million heart a3acks every year -Heart disease is the leading cause of death in the US -2,000 people in the US die daily from heart disease, ~600k/year -1 in 4 Americans will die from heart disease -World-wide, 17 million people per year die from heart disease 2 The Economic Costs to Society • By 2030, the cost to the US of heart disease will exceed $1T/year* • Bringing a single drug to market costs ~$2.6B** and these costs are rising ~10%/year • 40% of all drugs fail in clinical trials due to adverse cardiac eﬀects • Drug clinical trials in 2013 cost ~$10B, There were 6200 trials in 2013 3 The Economic Costs to Society • By 2030, the cost to the US of heart disease will exceed $1T/year* • Bringing a single drug to market costs ~$2.6B** and these costs are rising ~10%/year • 40% of all drugs fail in clinical trials due to adverse cardiac eﬀects • Drug clinical trials in 2013 cost ~$10B, There were 6200 trials in 2013 Heart on a chip technologies for drug tesVng and development Implantable cardiac Vssues for repairing damaged hearts Success in our ERC will lead to major economic beneﬁts and a new mfg industry *CDC: >$818B direct medical costs, lost producSvity >$275B 4 Our Vision Use scalable nanomanufacturing technologies to produce clinically transformaSve cardiac Sssues Cell-MET NERC 5 A Bo3om-up Approach This is our “Transistor” Flexible Polymer Post This is our “Integrated Circuit” BeaSng Cardiomyocytes Focal A3achment Point (Au-Thiol-Protein) We will design, build, and test integrated 3D Sssue patches that can be used for cardiac repair. 6 The Engineering Genealogy of Our Vision Nano-Mechanics Cell Engineering Atomic Calligraphy Organic Vapor Jet PrinSng OpScal Sensing/ActuaSon Lab on a Chip 7 The Engineering Genealogy of Our Vision Nano-Mechanics Cell Engineering Build dynamic funcSonal scaﬀolds using nanofabricaSon tools Exploit cardiac cell biology, stem cell techniques, and cell mechanics in 3D Sssue plaiorms Atomic Calligraphy OpScal Sensing/ActuaSon Use advanced microscopy and optogeneScs tools to image and control cells in Sssue Create funcSonal Sssue patches with increasing complexity, to be used as enablers for a heart-repair industry. Lab on a Chip Organic Vapor Jet PrinSng Develop cellular “glues” for focal cell a3achments on scaﬀolds 8 Three Plane Diagram 9 Our Ten Year Vision 10 Our Workplan 11 Our Workplan 1 1 2 1 1 3 2 2 4 2 TB 3 5 6 3 8 7 4 4 6 3 5 9 4 5 28 Interrelated Tasks 7 10 5 12 Three Plane Diagram TB 7 2 2 2 4 10 3 6 4 1 36 9 4 15 1 6 2 8 3 5 1 34 5 2 2 1 5 4 7 1 13 Strategic Planning Dynamics Strategic goal: Develop 3D Sssue plaiorms and cardiac patches using enabling new science and engineering tools in cell biology, nanofabricaSon tools, and opScal engineering. Work plan: Pursue coordinated projects that aim to produce progressively more complex 3D Sssue structures involving interdisciplinary collaboraSon among Thrust Areas. 14 Listening to the Demand Signals 15 Listening to the Demand Signals Inputs From: • • • • • • • • • CELL-MET faculty who are world-class scienSﬁc leaders ScienSﬁc Advisory Board Industrial PracSSoners Advisory Board Workforce Development Advisory Board Academic Policy Board Council of Deans Annual NSF review process and their referees Workshops and conferences hosted by CELL-MET Inputs from other funding agencies Senior Leadership Team 16 The CELL-MET Annual Planning Cycle Annual MeeVng (March) Progress Report (February) Planning/BudgeVng (Summer) Annual Retreat (May) Program Year Begins (October) 17 The CELL-MET Annual Planning Cycle Annual MeeVng (March) PotenSal mid-year correcSons Progress Report (February) NSF, SAB, NSF Review Panel, IPAB, WDAB feedback Planning/BudgeVng (Summer) Analysis and input from CELLMET Team Annual Retreat (May) Review and funding decisions on ongoing programs and seeds Program Year Begins (October) 18