Lecture Note
CELL-MET ERC Vision and Strategic Planning
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University:
Boston University -
Course:
ENG ME 302 | Engineering Mechanics II Academic year:
2022
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Views:
44
Pages:
18
Author:
SpaceCadet101
CELL-MET ERC:
Vision & Strategic Planning Heart Disease
-Americans suffer one million heart a3acks every year
-Heart disease is the leading cause of death in the US
-2,000 people in the US die daily from heart disease, ~600k/year
-1 in 4 Americans will die from heart disease
-World-wide, 17 million people per year die from heart disease
2 The Economic Costs to Society
• By 2030, the cost to the US of heart disease will exceed $1T/year*
• Bringing a single drug to market costs ~$2.6B** and these costs are rising ~10%/year
• 40% of all drugs fail in clinical trials due to adverse cardiac effects
• Drug clinical trials in 2013 cost ~$10B, There were 6200 trials in 2013
3 The Economic Costs to Society
• By 2030, the cost to the US of heart disease will exceed $1T/year*
• Bringing a single drug to market costs ~$2.6B** and these costs are rising ~10%/year
• 40% of all drugs fail in clinical trials due to adverse cardiac effects
• Drug clinical trials in 2013 cost ~$10B, There were 6200 trials in 2013
Heart on a chip
technologies for
drug tesVng and
development
Implantable cardiac
Vssues for repairing
damaged hearts
Success in our ERC
will lead to major economic benefits and a new mfg industry
*CDC: >$818B direct medical costs, lost producSvity >$275B
4 Our Vision
Use scalable nanomanufacturing technologies to produce
clinically transformaSve cardiac Sssues
Cell-MET NERC
5 A Bo3om-up Approach
This is our “Transistor”
Flexible
Polymer
Post
This is our “Integrated Circuit”
BeaSng Cardiomyocytes
Focal
A3achment
Point
(Au-Thiol-Protein)
We will design, build, and test integrated 3D Sssue patches that
can be used for cardiac repair.
6 The Engineering Genealogy of Our Vision
Nano-Mechanics
Cell Engineering
Atomic Calligraphy
Organic Vapor Jet PrinSng
OpScal Sensing/ActuaSon
Lab on a Chip
7 The Engineering Genealogy of Our Vision
Nano-Mechanics
Cell Engineering
Build dynamic funcSonal
scaffolds using
nanofabricaSon tools
Exploit cardiac cell
biology, stem cell
techniques, and cell
mechanics in 3D Sssue
plaiorms
Atomic Calligraphy
OpScal Sensing/ActuaSon
Use advanced microscopy
and optogeneScs tools to
image and control cells in
Sssue
Create funcSonal
Sssue patches with
increasing
complexity, to be
used as enablers for
a heart-repair
industry.
Lab on a Chip
Organic Vapor Jet PrinSng
Develop cellular
“glues” for focal cell
a3achments on
scaffolds
8 Three Plane Diagram
9 Our Ten Year Vision
10 Our Workplan
11 Our Workplan
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28 Interrelated Tasks
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12 Three Plane Diagram
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13 Strategic Planning Dynamics
Strategic goal:
Develop 3D Sssue plaiorms and cardiac patches using enabling new
science and engineering tools in cell biology, nanofabricaSon tools,
and opScal engineering.
Work plan:
Pursue coordinated projects that aim to produce progressively more
complex 3D Sssue structures involving interdisciplinary collaboraSon
among Thrust Areas.
14 Listening to the Demand Signals
15 Listening to the Demand Signals
Inputs From:
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CELL-MET faculty who are world-class scienSfic leaders
ScienSfic Advisory Board
Industrial PracSSoners Advisory Board
Workforce Development Advisory Board
Academic Policy Board
Council of Deans
Annual NSF review process and their referees
Workshops and conferences hosted by CELL-MET
Inputs from other funding agencies
Senior
Leadership
Team
16 The CELL-MET Annual Planning Cycle
Annual MeeVng (March)
Progress Report (February)
Planning/BudgeVng (Summer)
Annual Retreat (May)
Program Year Begins (October)
17 The CELL-MET Annual Planning Cycle
Annual MeeVng (March)
PotenSal
mid-year
correcSons
Progress Report (February)
NSF, SAB,
NSF Review
Panel,
IPAB,
WDAB
feedback
Planning/BudgeVng (Summer)
Analysis
and input
from CELLMET
Team
Annual Retreat (May)
Review and
funding
decisions
on ongoing
programs
and seeds
Program Year Begins (October)
18
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