University:
Boston University
Course:
GMS MI 823 | Special Topics in Microbiology
Academic year:

2022
Views:

160

Pages:

8
Author:

5CelestialChronicle

White Blood Cells (Leucocytes) Con chuideat Characters Mobile ② True Cells Gunk: 4000-11:000/mm² Act by Phagocytosis • Antibodies formation • Memory Cells formation Tand Blympecytosis Leukopoiesis: Occur in BM by CSF. Colony stimulating Pluripotent - Uncomitted-stem Cells Factory Leukopartin Can Cic55e the Plasenta Comitted stem Cells "only WBC" myeloid Line Ly mpheid Line Granulocytes Monocytes Lymphocytes Thymus Types LGranulocytes Neutrophils: 50-70% Eosinophils: 1-4% Basophils: 0-4% histamin Lo Agranulocytes Lymphogtes: 20-40% • Monocytes: 2-8% Macrophage in tiss acdophil Leucopenia . +WBCs drugs Leucocytosis •↑ WBCS to 20:000 due to • acute inflamation ) torsilitis( high-functional jo WBC Leukemia ↑↑ WBC.. Very high due to malignancy (high-Non-function Ratiba Compicmand mucleus enzymes Azurophil (Primary) grarmules Lysosome Lactofenin Cathelscidin chevron Specific (Seamdary) grende Definit classi Primary Granule * Function Ingest of Kill bacteria 2 + Mechanism. 1. Margination WBC stick to Capillary Wall 2. Diapedesis Wac Squeeze through Capillary pores 3 Ameboid movement in tissue to reach bacteria elastase 4-chemotaxis ve bacteria attract bac neutrophila Gure bacteria repel neutrophils Metalloproteinease "collagenas. Phagocytosis, ingestion of bacteria by endocytosis Secondant granules degranulate their Contents into Gram ECF> Phagolysosome "Burst Primary granules degranulate their Contents into Phagoly sasome ECF Immunity Definition: ability of body to resist infections- Classification: Innate immunity [6] Acquired immunity. •Innate - Immunity :. special- Characters • Non specific = Not needed recognition • Since born Not needed previous exposure • Rapid = act directly against foriegn Cells. • Include 1. Mechanical & chemical bammers →Covering Gitt relium (skin - GIT - UT-RT) Mucus Membrane Frist Line defence 2. Cells :- →Microphage Neutrophils - Esinophils →Macrophage: Monocytes - Macrophages →Natural-killer-Cell: Non-T-Non-B-lymphocytes!! NB: NK-Cell 1 defense against Viral & malignant Celle) ( 3. Humoral factors Lysosymes polysaccharides Lyse bacteria. Inter feron protems act antiviral only Virus 8-INF →NK-Cells/macrophages CRP acute protern Reactive prote - inflamation properdin Symtem. proteins Complement omplement System: 11. proteins (CCa)Antibodiesit by classic pathway by Properdin pathway by Mannose-binding - Lectin СЗа зв Csa CSB Functions of Complements • In Fetus 1. Agglutination 2. Opsonization: adher many micro organism Coat bacteria to be easy engulfed 3. chemotaxis attract COBCS to Site of infection 4. Neutralization: bind to toxin to become non-virulent 5. Direct killing by insertion of perforin Cell Lysis B-Lymphoogte • Acquired-immunity Characters: • Specific 1º recognize antigen • Acquired = require previous exposure • Memory Cells (and exposure to Same antiyen→ Fast-Strong response) Humoral immunity • depends on B-Lymphoutes . Kill bacteria by antibodies Cellular immunity • depend on T-lymphocytes • Kill Virus - Fungas by Cellular products • also: involved in allergy - transplant rejection