University:
Kentucky State University
Course:
CHE 315 | Biochemistry
Academic year:

2021
Views:

191

Pages:

17
Author:

folclord7m

Biosynthesis of Glycerophospholipids also known as Phosphoglycerides or Phosphoacylglycerol Lippincott’s Ch 17 FATTY ACID G L Y C E R O L FATTY ACID PHOSPHATE ALCOHOL PHOSPHOACYLGLYCEROL 1 O ║ O CH2O-C-R1 ║ I R2C-OCH I CH2O- P Phosphatidic Acid Can Form Ester with Alchol: - Serine - Inositol - Ethanolamine - Glycerol - Choline Phosphatidyl - HO-CH2 CH3 Ethanol HO-CH2CH2-NH3+ Ethanolamine HO-CH2 CH2 –N(CH3)3+ Choline HO-CH2 CH-NH3+ I COOSerine 2 O O ║ CH2O-C-R1 I R2C-OCH + I CH3 CH2O- P - O-CH2 CH2 –NCH3 CH3 ║ Phosphatidyl Choline (Lecithin) 3 4 ? ?? 5 FATTY ACID G L Y C E R O L FATTY ACID PHOSPHATE ALCOHOL Degradation of Phospholipids: Phospholipase A1 Phospholipase A2 Phospholipase C Phospholipase D 6 7 Biosynthesis of Triacylglycerol & Phosphoacylglycerol FATTYACID FATTYACID G L Y C E R O L FATTYACID FATTYACID G L Y C E R O L FATTYACID PHOSPHATE ALCOHOL TRIACYLGLYCEROL PHOSPHOACYLGLYCEROL 8 Phosphotadic Acid is Common Intermediate F A T T Y A C ID G L Y C E R O L F A T T Y A C ID PHOSPH ATE PHO SPHO ACYLG LYCERO L FATTY ACID G L Y C E R O L FATTY ACID PHOSPHATE ALCOHOL Biosynthesis of glycerophospholipids Alcohol1 Phosphate Alcohol2 Transfer ~(Phosphate-Alcohol1) to Alcohol2 or Transfer ~(Phosphate-Alcohol2) to Alcohol1 9 Formation of Activated Carrier Alcohol- P P ~ P ~ P Ribose-Cytosine Alcohol- P ~ P P ~ P Ribose-Cytosine CDP-Alcohol Pyrophosphate Synthesis of Phosphatidyl Inositol Transfer or Phosphatidic acid to Inositol CDP-diacylglycerol CMP + Inositol Phosphatidyl Inositol 10 Synthesis of Phosphatidyl Choline Transfer or Phosphocholine (Ethanolamine) to Diacylglycerol CDP-Choline CMP Diacylglycerol Phosphatidyl Choline 11 Alteration of Polar Head Group • Exchange of the Polar Head Group Phosphatidyl Ethanolamine • Phosphatidyl Serine Serine Ethanolamine Alteration of Polar Head Group • Decarboxylation of Phosphatidyl Serine Phosphatidyl Serine CO2 Phosphatidyl Ethanolamine 12 Alteration of Polar Head Group • Methylation of Phosphatidyl Ethanolamine S- Adenosyl Methionine (SAM); Methyl donor Phosphatidyl Ethanolamine CH3-S-CH2CH2-CH-COOI I Adenosine NH3+ S- Adenosyl Homocysteine Phosphatidyl Choline S-CH2CH2-CH-COOI I H Adenosine NH3+ 13 Remodeling Phospholipids: Changing the Fatty Acid Ether Glycerophospholipids 14 Platelet-activating Factor 15 Surfactant Action of Phospholipids 16 17

Biosynthesis of Glycerophospholipids

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