University:
York University
Course:
CHEM 1000 | Chemical Structure
Academic year:

2021
Views:

303

Pages:

3
Author:

Niklas

Fischer Projection: Sugars, Amino Acids DRAW C chain in straight vertical line Ea. C has 2 subst. 1 subst. subsequent C in chain Ex. Simple - 1 chiral center R NH₂ | COOH | H | R Amino Acid D-AA A-C-B | | C C | | up down L-AA A-C-B | | C C | | down up C=O | H | HO-C-H | H | OH Aid or aldehyde prep; but doesn't have to be. 2 chiral centers C=O | H | HO-C-H | H | OH Non-chiral center Enantiomer C=O | H | H-C-OH | H | OH Assign absolute configuration CH₃ | CH₃-C-OH | H *CW = R Converting Fischer Projections: H O | || H-C-OH || | || HO-C-H || | || CH₂OH || H O | || H-C-OH || | || HO-C-H || | || CH₂OH || Nomenclature of Alkene Isomerism: X=X X=X X=X X=X cis/trans E/Z CIP Rules: Pick one C atom in the double bond Note Substituents on that C atom Assign Priority (to substituents) - Using CIP Rules Det. Relationship (in highest priority groups) on C1/C2 Assign: Opposite: E Same: Z Ex: H Br | | C=C | | Me H Z Isomer (same side) H Me | | C=C | | Br H E Isomer (opposite side) H F | | C=C | | CH₃ F Neither!