Q1: Choose the correct answer [12M] 1. Which of the following is NOT a feature of a promoter? A. Enhancer B. Silencer C. UTR D. TATAA box E. All are correct 2. Which of the following statements is False? A. Transcription is regulated by Histone modification (e.g., acetylation) B. Hormones regulate transcription by activation of specific transcription factor C. Enhancer and Silencer control translation- D. Expression of globin genes is age-dependent 3. The nucleotide sequence surrounding the translation start site (TSS) for a protein is shown below. A mutation occurred at "A" nucleotide, indicated by the arrow. What is the kind of mutation at this position? 5. CAP AGGAGCAACCGUAGGCCCAUGGGUCCAUGGCGCAGA... TSS A. Missense B. Nonsense C. Silent D. Frameshift 4. All of the following modifications occur for pre-mRNA except one? A. Removing of introns B. Addition of m G-cap C. Addition of poly A-tail D. Binding to the large subunit of the ribosome 5. Which of the following is NOT an effect of a mutation? A. Prevents a protein from forming B. Lowers the amount of protein C. Adds a new function to a protein D. Any of the above can occur 6. A Caucasian boy was referred to a children's neurology department. At the age of 15, his atability to read, write. and calculate decreased. His neurological examination revealed Huntington's disease. Which of the following expanded repeats is the major cause of HD? A. CAG B. GAA C. CTG D. CGG 7. Which of the following genetic diseases results from deletion of phenylalanine in the coding sequence region? A. Friedreick's ataxia B. Hemophilia B C. Tay sach's disease DCystic fibrosis 8. What is the type of mutation that causes a section of amino acids (not normally found) to be introduced in the protein? A frameshift mutation B. Inversion mutation C. Chain termination mutation D. Mis-sense mutation 9. What is the meaning of the following mutation c. [83_84insA, 103G>A]? A . Insertion and substitution mutations in two different alleles in the genomic region B. Insertion and substitution mutations in two different alleles in the coding region C Insertion and substitution mutations in one allele in the genomic region D. Insertion and substitution mutations in one allele in the coding region 10. Which of the following genetic disorders is caused by unequal crossing-over? A. Hemophilia B B. Sickle cell anemia C. Red-green color blindness D. All are correct 11. Which of the following is NOT a property of genetic code? A. Is composed of a nucleotide triplet B. Is overlapping C. is degenerate D. Is nearly universal 12. Suppose that you have the following wild-type DNA sequence 5' ATTCGC 3'. Which of the following show a point mutation? A. AATTCGC B. ATCGC C. ATCCGC D. All are correct

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