Regulation and Control of Hormones

Reagulation and control of hormones, Direct Control:- Substant Regulat Hormones and Hormone Regulat Substant. EX: Insulin&Glucose, PTH&C, Aldestron义。 this thormones regulat by them Self noneed for bypothalamus. 2) Negative feed Back: *most comman type * most of hormones Regalat By Hypothalams pitatary Axies. TRH termediate TSH TSH Relating munes aut Like Autocrin to stop teasing more 3) Positive feed Back *By Support and Accelerat Secretion. EX: Labor oxytocin, milk excretionis, oxytocin, Lisung in oulalation By estrogen. Rhythmic secretion: Circadaln early Evening *Ghange By Night/day cycle ing Ex: Cortisol, melatonin, GH. Palsatil Secretion: "every hour change every hour *most of hypothalamus Hormones. *Line cortisol. Diffecult to measure In Blood So we need athr collection. Mode of hormones Action: Synege - Adrinalin+NE +T>T+ 1+1=3 Permiss: PTH +vitD 011-2 Antagonist intule+ Glucagon 1+1=0 Endocrin disorders: Primary Gland 2ndry Pitutry tortery Hypothalumas Elemination of hormones: *By Hepatic and Rinal URin Transport of hormones Active peptid and proteins Free in plasma Shart duration inactive Steroid, thyroid Bind to Plasma protein long duration" Site of hormones receptors: *cell membrane Receptor peptied protien catacholamin. nuclair Receptor Steroid and 13. 14 * Cytoplasmic Receptor Up Regulation of Receptors. Khamber of IR on target cell Duo to Block of receptor m Down Regulation of Receptors: *Number of (R on target. cell Duo to aver stiunuludon mechanism of Receptors Extracellular (R) Ionotropic channel medaited (R) Fast *Excrtatory (Na, Con Yinflux Inhibtorgas (Ct influx) (Kexllax) Enzyme Linked Adipotissue G-protein coupled Adeny! cyclise C-Amp. Phospholipell Az IPsr DAG. Calmedulin. inter cellular(R) *Cytoplasmic and nuclair. *Act on gene IMRNA, Tearscription, Responed Ex