University:
Franklin University
Course:
BIO-406 | Genetics
Academic year:

2020
Views:

249

Pages:

13
Author:

6AstralAdventurer

        One whose genome has been changed to carry gene from other species. An animal in which there has been a deliberate modification of its genome. These are useful tools in biomedical research. Example of trangenic animals Mouse cow fish Goat dogs Sheep horse Rabbit guinea pigs  • • • • • • Advantage Increase the growth rate Improve the disease resistance Improve the food conversion rate Increase the muscle mass Improve the nutritional value Improve the wool quality  • • • • Disadvantage Inserted gene has multiple function Breeding problem Some time lead to mutagenesis and functional disorder Low survival rate of transgenic animals Why transgenic animals being produced? 1.Specific economic traits alpha -1 anti-trypsin for treatment of human Emphysema. Alpha lactalbumin 2.Disease models effective treatment studied  DNA microinjection  Retrovirus –mediated gene transfer  Embryonic stem cell mediated gene transfer  Pronuclear method