University:
Glendale Community College
Course:
BIO160 | Introduction to Human Anatomy and Physiology
Academic year:

2020
Views:

488

Pages:

4
Author:

milheress5

Biochemistry in Perspective §HIV is the causative agent of acquired immunodeficiency syndrome (AIDS) §Belongs to a unique group of RNA viruses called retroviruses, which contain reverse transcriptase Figure 17J HIV Structure Biochemistry in Perspective §HIV is an enveloped virus with a cylindrical core within its capsid §The core contains two copies of the (+)-ssRNA, reverse transcriptase, ribonuclease, and integrase §HIV binds to T-4 helper lymphocytes of the immune system Figure 17J HIV Structure Biochemistry in Perspective §Once bound, HIV fuses with the host cell membrane and releases ssRNA and reverse transcriptase §Immediately makes ssDNA from the viral RNA, which is integrated into the host cell chromosome by the integrase enzyme Figure 17K Reproductive Cycle of HIV, a Retrovirus Biochemistry in Perspective §Proviral components are not activated until the T cell is activated by the immune response §Newly synthesized virus buds from the infected cell §Within hours, an infected host cell’s mRNA has been replaced with viral RNA and the virus has taken over the cell Figure 17K Reproductive Cycle of HIV, a Retrovirus