Methylene Blue Health Benefits Methylene blue helps mitochondrial respiration and helps improve brain energy metabolism. It improves cognitive performance and prevents neurodegeneration. Methylene blue is a parent molecule for hydroxychloroquine and chloroquine, off-parent drugs were used to treat malaria and Covid-19. Methylene Blue is used in emergency rooms all around the world. Its uses are to prevent and treat dementia, post-stroke, and other brain injuries, cognitive enhancement, and general optimization. Gonzalez-Lima Ph.D is an expert in Methylene Blue. She states “With methylene blue, we have been able to show all of those [benefits],” Gonzalez-Lima says. “Our group was the first to map the effects of methylene blue in the brain of humans and show its effects on improving brain metabolism, blood flow and memory function.” It was first used medically for Malaria in 1890 in Germany. In the past it was also used to treat urinary tract infections. It’s used in the hospitals since it’s the only known antidote for metabolic poisons. It is a hormetic drug, so low does have the opposite effect as high does. Low dosages have an antioxidant effect, while high dosages are used to kill bacteria and tumor cells. Gonzalez-Lima research on how low dose benefits over the longer term like neuroprotective benefits and cognitive enhancement. “Our body uses electrons as part of the electron transport chain that happens inside mitochondria, and these electrons, moved along through the mitochondria, are generated from electron donors that we produce by the foods that we eat. All the foods that we eat, the only way they contribute to energy is by producing electron donors. They donate these electrons to the electron transport inside the mitochondria. The ultimate electron acceptor in nature is oxygen. That's why the process of removing electrons from a compound is referred to as oxidation. In mitochondria, this process is called oxidative phosphorylation. The electron transport is coupled with the phosphorylation of adenosine to eventually produce the adenosine triphosphate molecule (ATP). Methylene blue is an electron cycler. It's an auto oxidizing compound. So, methylene blue donates its electrons directly to the electron transport chain, it obtains electrons from surrounding compounds, and maintains oxygen consumption and energy production. By doing this, it helps oxygen to be fully reduced into water. Methylene Blue can also help with impaired blood flow.

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