Pharm Review Immunology Antineoplastics

Pharmacology Review Immunology/ Antineoplastics 1. Etoposide, part of the ICE protocol for aggressive lymphoma and progressive neuroblastoma is derived from Mandrake plant 2. Bevacizumab (Avastin) is a monoclonal antibody that inhibits VEGF 3. Which monoclonal antibody is used most often to treat Crohn’s Disease? Infliximab 4. Which naturally derived anti-neoplastic agent has a maximum lifetime dose of 550mg/m2 Doxorubicin 5. Which class of antineoplastics is considered treatment of choice for tamoxifen-resistant tumors Aromomase inhibitors Letrozole, exemstane, anastrozole 6. Glucocorticosteroids are used for their ______ action in the treatment of lymphoma. 7. Tendon rupture is a potential ADR of which class of drugs glucocorticoids 8. Which drug interaction (agent) can cause a significant decrease in the metabolism of azathioprine allpurinol 9. Mesna is administered with cyclophosphamide to decrease the incidence of this ADR; hemorrhagic cystitis 10. Thyroid disorders are associated (16%) with which monoclonal antibody alemtuzamab 11. Rituximab targets which CD receptor CD20 12. Bicalutamide and nilutamide belong to which class of drugs Androgen antagonists!! 13. Which agent is converted to 6-MP in vivo Azathroprine!!!! 14. IL-2 has been used in the treatment of Melanoma and renal carcinoma !!! 15. Ondansetron targets 5h3 receptors. 16. Name one anti-neoplastic agent that is derived from the periwinkle plant Vinca alks 17. Which immune modulating agent can be used topically in the treatment of molluscum contagiosum Imiquimod 18. Tumor lysis syndrome can be prevented by the administration of this first-line drug Rituximab!!!!! 19. Tacrolimus is eliminated via Feces!!! 20. Letrozole belongs to the aromatase inhibtor inhibitor class of drugs. 21.Asperiginase anti-neoplastic agent derived from E.coli. 22. Doxorubicin is associated with this significant SE, which limits the lifetime dose of the drug cardiotoxicity 550 mg 23. Ondansetron is Pregnancy Category B 24. The primary indication for cyclosporine transplants 25. Chimeric monoclonal antibodies are a mixture of ___ and ___ antibodies. They are designated by xi in their name. 26. FSH and LH are two hormones secreted by the pituitary gland that act to increase production of estrogen and progesterone in females. 27. Flutamide belongs to the androgen antagonists class of drugs. 28. MOA of rituximab includes CD20 29. Anti-neoplastic agent derived from the yew tree Paciltaxel and docetaxel 30. MOA of mycophenolate mofetil:_____________. 31. Created from B lymphocytes and cloned to interact and neutralize a single antigen type inhibits purine synthesis, inhibits t and B cells 32. Major toxicity associated with cyclosporine Nephrotoxicit and gingivial hyperplasia!!!!! 33. Protocol for aggressive lymphomas and neuroblastoma: ICE: stands for these agents Cisplatin, top aide, ifosphamide 34. Significant SE seen with irinotecan (not myelosuppression) cramping and diarrhea 35. Trastuzumab targets the ___HER2+ receptor to prevent tumor growth in breast cancer. 36. Rituximab is a monoclonal antibody used in the treatment of Lymph cancer. 37. Pyrimidine synthesis inhibitor used in the management of many autoimmune diseases that must be “loaded” due to a very long half-life____________ 38. Infliximab binds to and inhibits TNF to prevent inflammation. 39. Commonly used nitrogen mustard alkylating agent used in the treatment of leukemias Cyclophasphamide – alopecia and mouth sores!! 40. Nitrosurea alkylating agent used in the treatment of brain tumors (lipophilic- able to pass into the brain)- IV agent CARMUSTINE!! 41. BEP is used in the treatment of testicular cancer. The P stands for which platinum agent? ___________ 42. Intrathecal administration of this agent is used in the treatment of CNS tumors involving the meninges.____ ________. 43. Folic acid antagonist used in the treatment of mesothelioma________. 44. Purine antagonist used as add on therapy in the treatment of ALL; also used in the management of autoimmune diseases.___________ 45. Purine antagonist used in the treatment of CLL. _________ 46. Pyridine antagonist; administered IV or PO; topically used in the treatment of basal cell skin cancer, actinic keratosis, and HPV __________. 47. New pyrimidine antagonist; administered with capecitabine for the treatment of advanced breast cancer. _______ 48. Pyrimidine antagonist that is metabolized to 5-FU by tumor enzymes; used in the treatment of solid tumors.________________ 49. Agent used concomitantly with cyclophosphamide to prevent hemorrhagic cystitis _____. 50. Mainstay of RA therapy____________. 51. Chimeric monoclonal antibody TNF inhibitor administered via IV infusion Q8 weeks ___________ 58. Anti-CD 20 monoclonal antibody used to treat RA and hematologic neoplasms; severe infusion reactions are seen RETUXIMAB! 52. May be administered after methotrexate chemotherapy to resume blood cell production LEUCOVORIN 53. The use of glucocorticosteroids is associated with ___________syndrome. 54. Original angiogenesis inhibitor monoclonal antibody Bevacizumab 55. Therapeutic vaccine utilized in the treatment of superficial bladder CA BCG 56. Proteasome inhibitors used to treat multiple myeloma (3) ________________ 57. Class of epigenomic targeted drugs approved for use in cutaneous T cell lymphoma ____________ 58. Class of agents used as first-line therapy in early emesis management ________________ 59. BENZODIASPIENES!!! drugs can be given to alleviate anticipatory nausea. 60. Diarreha and cramping is a significant non-myeloid SE seen with irinotecan. 61. _________________ - class of antineoplastics that restore the natural function of the immune system 62. Most important lab value to monitor when administering erythropoietin – ___________ 63. Universal ADR of the monoclonal antibodies used in managing autoimmune diseases _________________________ 64. Cytokine release syndrome may be seen after administration with which antineoplastic agents – _______________________ 65. Vincristine has _________________ as part of its ADR profile