Hematology Questions 2019

11':<-.gjcal CommrtH-e The Un!Yenftv of )ofdarl Hematology questions: 2011 1- A 61 year old man has had dull, constant back pain for 3 months. He recently developed a cough productive of yellowish sputum. On PE there are crackles at the right lung base. A plan film radiograph of the spine reveals seve rail to 2 em lytic lesions of the vertebral bodies. Laboratory studies show normal Na, K, Cl, C02, blood glucose, urea 49 mg/dl, cr 5 mg/dl, total protein 8.3 g/dl, albumin 3.7 g/dl, alkph 176 U/L, AST 45 U/L, ALT 22 U/L. a sputum culture grows strept. Pneumonia. Which of the following pathologic findings is most likely to be seen in a bone marrow biopsy from this patient? a- Scatterd small granulomas b- Nodules os small mature lymphocytes c- Occasional reed-sternberg cells d- Numerous binucleated and trinucleated plasma cells e- Hypercellularity with many blasts 2- A 72 year old mn has had increasing fatigue for the past year. On PE there are no abnormal findings. Laboratory studies show aHgb of 9.1 gm/dl Hct 27.9%, MCV 96 fl, WBC count 3700/microlitre, and platelets count 125000/microlitre. The WBC differential count on the peripheral blood smear shows 53 segs, 5 band, 2 metamyelocytes, 1 myelocyte, 32 lymphs, 7 monos, and 5 nucleated RBCs/100 WBCs. He has a negative direct and indirect coombs test. Which of the following diseases is he most likely to have? (NOT SURE IF IT'S CORRECT ANSWER) a- Metastatic carcinoma b- Chronic alcoholism c- Malabsorption d- Hemoglobinopathy e- Chronic blood loss 3- The most frequent genetic abnormality which causes sever hemophilia (A) is: a- Inversion of intron 22 (int 22 inverse) of factor VIII gene b- Inversion of intron 1 ( in 1 inverse) of factor VIII gene c- Nonsense mutation leading to a stop codon d- Missesnse mutation leading to a substitution of an amino acid p1 2 1-.!edicoj CommitNt Tht UNYentty of Jordan e- Single base deletion in exon 18 4- A 25 year old male patient was reffered with the diagnosis of acute myeloid leukemia. He was found to have Hb 8gm/dl, WBC 80000/ul, platelets count 17000/ul. Blood film showed 80% blasts with bilobed appearance. BM was heavily infiltrated by blasts with abundant cytoplasmic granles and aur rods. Granules were positive for myeloperoxidase, but negative for butyrate esterase. Blasts were CD33 and CD13 positive. Cytogenetics studies were done. Which of the following cytogenetic abnormalities is most likely in this patient: a- T(15;17} b- T(8;16) c- T(8:21) d- T(1;22) e- T(9;22) 5- 69 year old male presented with chest infection. His blood count showed: Hb 8g/dl, WBC 2100 with 20% neutrophils, platelete count 28000, blood film showed 12% blasts. Bone marrow examination revealed myelodysplastic changes with 18% blasts. Cytogentetics sowed deletion of chromosome 7. What's the likelyhood of survival as judged by the international prognosis score (IPSS) of myelodysplastic syndrome (MDS): a- 46 months b- 34 montha c- 7 months d- 24 months e- Normal life expectancy .. 6- 19, M, malaise for 3w, has pharyngitis and tende LNs, has peripherally "atypicallymphoctes" --> CMV, captured from personal contact ! !essara7a rna fhemetshufekret esso2al wellashuhowweh a91an ! ! if anyone of those who attended could help:)))) F13