University:
Southern Alberta Institute of Technology
Course:
CHEM182 | Chemistry
Academic year:

2024
Views:

162

Pages:

3
Author:

Simran

GRIGNARD REACTIONS *Grignard reactions refer to the reaction between a ketone ov aldehyde group with a gagnard roogant to foxin. carboxylic acids primary alcohols, secondairy alochols or ternary alcohols = Carignard reagents ove organometallic compounds conteroning magnesium and halide (organomagnesium halide). LD Made by heating a halogenicalkane with magnesium in dry ether (solvent) under veflux * Peflox wolves bearing the chemical reaction for a speciộc amount of hine, while continually cooling the sepour producat back into liquid fares, osing a condensers hence retiming to the flask as a condensate. This guarantees that the tempevahine of the reactors vomains coustint LD Magnesiom is inen covalently bonded to the alkyl grove and the halogen R-X + Mg R-Mg-x Bromoalkanes ave move preffered in gagnard vengants R-x LP R-Br + Mg R-Mg-Br = Grignard vengants undergo the following reactions * Process taves place in 3 steps 1. They react with CO2 to form carboxylic acids a) Formation of Gangnard reagants. CH3 CH₂CH₂ Br malonge CH3CH2CH2 Mg Br 6) Reaction with anotser catalyst reagent CH3CH2 Cile My Br + CO₂CH₂CH₂CH₂ COOMgB 2) Hydrolysis vang a dileste acid, to obtain organic product Cil₂CH₂CH₂COOMgBr + H₂O CH3CH2CH2COOH + Mg(OH) B 2. Reaction with methanal to form primary alcohols This roncion also longthens the onion a) Formation of Gingnard reagents CHS MgBr Renches with another nosgant CHsMgBr + HCHO CH3CHOMB 2) Hydrolysis using a dilute and CHACH=OMgBr + H₂D→ CH3CH2OH + Mg(OH) Br & Reaction with aldehydes to foron secondary mloohols Formation of Comignard neagent CHSCHA CHA CHA By Male CH3CH2CH3 Cho My Br 6) Reaction with another vergaat CHSCH&CHICHI MgBr + CH3CH=CHO CHICHICH=CH-C-CHACHS @Hydrolysis using a dilute acid Omg B CHAOHOCH2CH2-C-CHICHS + H₂O CHICHICHACH2-CH-CHICHS + Mg(OH) Br 4. Dinchons with ketones to form terhany alcohol Formation of Congrond Reagants. CHA CHA B CH3CH2ig Br b) Venction saith another reagant CHOCH2MB + CHS-C-CHO CHE--Cнь Act CHS 2) Hadrolysis using a dilute oud. CH3-C-CH3 + H2O CH3C-CHS + Mg(OH). Be CHA CH3 Khe