HIV Retrovirus - Study Notes

HIV - retrovirus. General properties Morflilogy 90-120mm Spherical Single Mawlid PNN gouome Femine transcriplan- Enveloped pid chmactantic fiabzie Protien fglycoprotein 120 g gh 41]. Tissue Mchiem- Symmetry HIV geves -3 structural 1: gal, fol, env LG regulatory tat, nif L Yev 120 VG g2 41 124 antigen Pathogenesi *Soutte symptomate & asymptomate. Window palad in HIV! HIV antibodies to be infected, they harbor the never fot for life • Ona * Mode of transmision : sexual contad Porntial transmission Perinatal bbird tranfuvon Sharing needler abresen - Des required to cause of it much weither than 113 V. infuled motha to monite at or via breast mille. Muhanum * Mechemion of fatlingenen beide with cou tell Entry of Resta Antegrat (Revere travesatare in luutration & p41 of viral de DNA ie SRNA DNA Lunciating waith host chucomasane latency * Stagu HIV • Stage 1 - Amule HIV disease Entry of vores Destroye the Enfected Tulh Primary vöremea Flu like illness:-3to 6 wechs significant drop in cucubting with Stage 3- lymphadenopathy [Developed in 25-30% Jalent more than Enlarged brush nodes Icm In 2 of mou non bulaquos sites presting for alliset 3 months. - IIIV Pufiction. Fr cbwral latency Cou CD4 Unceblarned Unesplained dearshua fall with development of conctonetal feathery; more than 10% of body weight. loss; Mild opportunities Infections. •Stage 2: Asymptomatic stage Adequate immune response within I month: Vigenia 14 humoral firumenity inchn Claural lateny, not mechidereal HIV infected alls funcit in Apush nales ity y en enficat "gos on.. •Stage 5: AIDS usually & 200 ulle/ML. apel falt in 104 count - vinally High wink load kangeland Asue destroyed Opportunite sufidione! Neoplasia * Uluccal manfutation. - WHO. Stage! HIV Pu Pusstant Slave 2 [ Cuerplained med weight loss RTI Huber zate angular childs, oval ulcers hugal nal infection Stage 3 Aluplahud suvese mercylt love, cbrave desistiua peusstant fever. Oral candidieri, oval habry Muckoplabia Rilmonary tuberculons Severe hallwal inf fucunuqua, emprema etc. wutting Silicirathis stomaths, gangiusti, periode the Auite we "Unesplained anaele, neutrofura a Mago 24 HIV waiting andione Shu Umonth -Salmallan Parasitico Enf - Toxofarina, Frepea hungel win. Aspugillons •Oral manifestations ANVU - AIDS Fucditating HSV lunions. laudidlarin Lab diagnosis. • Ethical, Legal & barcolegial force with the HIV states. Thusfeer, foltering was badd be taken i 3Cs Content in wetten format - naw HIV the should not be witten Courvelling - motivate the Inductual. berlic test Ad detection Viru idat -Ab detecteth *Alon spuitic test word by all cant ratio •Ab detedien Sarcening test@ Verally takze lys titke Should be conformed. Detects HIV-IVG2 either sepredely a legehen. - •Not seful in diagnent dusly ardow Javel. ELISA Lorening test at blood bank 5 can sta Easy to suform & cost effutive Seruitive, pecatie & Diff bitt avalbble based on HIV Ag used re ELISA A detects IIIV Ab 47 4 → """ & Ag (pan) • lapal simple test "Developed for case of fuformance & Than 36 huge to subem -Des not requere slowed equipment Most commonly need in India. Flot arey + Dot blot assy Immunochromatography aray ELISA Llip stek / Comb test- Osupplemental test - Hersteen blot fest I enfrent bunun luocetence test. Radio Primuno Ppt bpt assay Spuler Hizlily Ab detect" method -Need Is Valislat the cervells & screenra tuts Epensive, labour hutende ned uputsal. Detects indhudud Ab ви мент antiqule fragment of HIV whille MIV whillel ane seprited by Pollacylamide ad electrophorera. Ag - No Complex affiar as dividet buds en • Deled of 104 cave audien Detect 24 core antigen. [p24 broner detectable 1-2 wave 14. -isful in diagnons during montes poterl •Detect of viral DNA → of the during welen fourd & wiral load meit draguas of HIV want Redhale Enllude RT-PLR Branled DNA assay NASBA Real thine RT-PCR for estimating wial lead. Treatment Higlily active and retro weal therapy (HAART] with combinat ART dugs -But cannot use 11129 meus production mpounds. Antfeutroviral drugs - TREAT ALL ART Zidovudine (AZT) 'Neverafene hamivudine Delaveholine And have Ritonaner. Dilanonhe -Etravinne Staudine Prophylaxis Gemcal measures I Sevening of bland devers halth education Medles, swinge should not be shend are butended to fement frenteral, mucous mentions, Universal becautions are butunted to & non intect skier spravures of berne fathogens health care markere to blond