University:
Camosun College
Course:
NURS132 | Promoting Health and Wellbeing
Academic year:

2023
Views:

479

Pages:

5
Author:

Aysha A

2010 EULAR/ACR Criteria for Rheumatoid Arthritis Score Criteria Joln's Affected 1 Large Joint 2-10 Large Jcing 1-3 Small Joints 4-10 Small Joins >10 Joints (at least 2 sindl Jint) Serology -ve RF + ACPA Low the RF on ACPA ...High the RF or ACPA Duration of symptoms 26 weeks 76 weeks Acute Phase Reactants Normal CRP and ESR Abnormed CRP ON ESR Patient with a score of 26 are considered to have detine RA Pathogenesis of Rheumatoid Arthriti's Genetic factors: HLA genes (HLA-DRB2 Enviserenid facts Non HLA Genes [ROL PTPN 22) • Infectiom Failure of self zlevance modification of self protein [cycle citrellated peptides (CCPS) Unreglades activation of Lymphytes Coy Kell (THIT Breu Response to self adigen (THI) INF Jed TNF Plasmarells Activation of Infim Recruitment of macrophages and & Cutoantibods ther Inflammatory cell, Tissue Injing Actuction of synoviat celts Destruction of Bone, Courtilage, Ligammy's and Tendors Pannu Formathim Fibroid banks Tcell activation cercars via: •TH, pathways: INF je •The pathaly Il D 5 INFJe of TL-D activate macrophage maorphase prodice TNFX TNF & 10. Central key pathogenic cytukhe in inteumchid anthuris •Actuates osteoclasts [RANK ligand RANK interactin • Inhibis osteoblasts [OKK-1 pathway) Generic factors MLA fartery. 1 HLA DR B1 04:- Hel Rijk 2. HLA DR B7 01:- causatpre 3. HLA OR BI 13:- Protecile Non HLA factors: 1. PADI 4 gere 2. PTPN 22 3. CTLA 4 4. Apum Environmental fators 1-Stocking! Strongest Risk factor, is PADI expresin n aishay of promotes protein citrullination. 2. Sica Bleeding- Hemostas's oncetanism foon Haemostasis, 3 things cure Required:- 1. Platelets 2. vasculas enclothellom 3. Coagulation cascade Steps in Coagulation cascade:- Endothelial Fnjung Vasoconstriction Formation of 1° hormostatic plag Formen of 2° hocmostktic plug Clot Formation steps of a Hemostasis: I. Platelet adhesion and stygan. •Occurs by interaction 6to Sp 16-1X and VNF. • Undergoes shape chere ie: nusind round, this 70 → spike Iprotiksh Shape change He Surface area Phosphatidyl sexre maves to the cutes suitse moves to Creates a ve chay 2. Palled aggregation: Que to interaction bow spb-ma 3. Platelet secretioni- 2 Types of Granules of Theis comparati • granules:- Pselectin, PDGF, PF4, TGFB, fibrinogen farns. • dense (delta granules:- ADP, Cole, serotam, epirga, Steps of 2º haemostars Coagulation cascade: te charge activates coagulation cascade. 2 pathways Intrinsic and sinc Intrinsic Tusive factar