University:
Camosun College
Course:
NURS132 | Promoting Health and Wellbeing
Academic year:

2023
Views:

339

Pages:

3
Author:

Aysha A

ENA NEPHRITIC SYNDROME RBCast hamabrica dysmorphi charecancel & Chematuria red cell, red-all casts in urine, azotemia, & oliguria, mild & mod hypertension Profeinda & cedene Diffuse Acake probterative glomentaruphritis. Cimmune complex modiated POSTSTREPTOCCOAL COLOMERULONEPHRITIS (Exogenous) (Endigenous Age: 6-10 yrs. 6SLE ✓ Follows streptococcal infection rather than primary infection of Kidney. Prinny streptococcal infection involves pharyne or skin (impetigo) ✓onf certain strains of group A B-hemolytic streptococciare nephritegenic Manifest only afte latent period of 1-4 weeks EVIDENCE TO SUPPORT INIMUNOLOGICAL BASIS Latal period-4 veeks, from the begining of production of antibodies and immune complexe formation Antibodies against streptococcal antigers -Anti-streptolysino - Anti-dergribonuclease (anti-DVAase B) -Anti-streptokinase -Anti-hyaluronidase Hypocomplementenia 11 11 :go/ patients, activatia & utilisation of compleruth" Immune-complex deposits EM Nomaruls with electron dense deposity of immune complexes Fluoresce Granular fluoresce Streptococcal antiguas in glamoreli: Nephritiu-ass. Streptococcal plasmin CNASPR receptor Mechanism of damage 2) Streptocer al pyogenic exotoxin B Megture complaces glamauli (SpeB) inflammation Bactivato glamorkes GROSS Kiding is enlagel, pale capsular surface & wrfex 1. GLOMERULUS ENCARGED HYPERCEWR GLOMERULUS -Infiltratin ly leucocytes Prol & svef Raves If mesangiad cells & Cendothelil -proliferation Parietal calls ( Poor progrosis La cresent shapel (B • obliteration of glamoralar capillong lumen. 2. TUBULES Confairs RED CELL CASTS & degerration of epithelial Cells of Tubules. 3. Interstium Oedene & inflammatory infiltrate 4. BVis uniemorkalle IMMUNIFLORER MICROSCOPY Granuler deposits of IgG, IgM, ond & in the mesingiun and alog to GBM grandt floresunce!! EM - SuBepithelial deposits of discrete, (amorphous) electron-dense deposits is choractristic feature CLINICAL COURSE Affected child devedlys malaise, fever, nauser, oliguria, & Hematria Ccmoky. or coland urine) Perforbital odeme, mild to cared bertension LAR Aso tire T Blood. Hy pocompl Blood uree ↑ seum creatinine ↑ uring Findings liguria mid protenoria Hematuria (smoky-coloured-urine) Microscopy-Red cell casts with fragnentation/.. PROGNOSIS ↳ children-good RAPIDLY PROGRESSIVE (CRESCENTIC) GLOMERULONEPHRITIS vid & progessive loss of Renal function; ass with Rapid Severe oliguria, and sigris of nephritic syndrome. death. class Type- Goodpasture syndrome antibody I Typo-11 Idiopathic Post infectious duman 18A nephropathy (imnine complex) deposition Typell! Idiopathic Wegener (ANCAS) granulomato sis Systemic vasculitis Path ElM-Granaler Fluorescence = 1° glomenler disease & systemer disease