University:
Camosun College
Course:
NURS132 | Promoting Health and Wellbeing
Academic year:

2023
Views:

388

Pages:

2
Author:

Aysha A

FOCAL SEGMENTAL GLOMERULO NEPHRITIS Characts & sclerosis that involves ong port of a capillary tifit of some glomeruli. (Focal) (Segmental)" CLASSIFICATION otrimag (Idiopathic) • Secondary Homebria+ Hypertension ↑↑ Fsas-ass prolenuria is Non-Selective • pour response to CORTIWITEROJP Virus HIV (Heroin) Sickle-cell-disease Masive obesity o Hereditary: AR FSGS due to 0 mutation in NPH S2 "Ipodocin & gene -actinin-4 PATHOGENESIS CIRC MEPIATORS-a damase (P) unknown injury to podocytes. show visceral epithelial domage (diffise effacement of foot proce55) Dep. of hyaline in Jomamli due to extrapment of plasma proteri & lipids in fociof injur where SUEROSIS develop MORPHOLOGY LIGHT MICROSCOPY Primary FSGS initiall involves of JUXTAMEDULLARY GLOMERULI & with the progession of the disease affects all lagn of CORTEX. Affects m some TUFTS + others TUFT'S NORMAL MICROSCOPIC FEATURES ci Increased A flestel Ameruli shows Cin Obliterated mesangial matrix capillar Lumen Cu) deposition of hyaline Leaked plasme protein) (N) Foang (Lipid lade) Macrophages/ Advapreds Stayes Sclerosis CALOBAL CALOBAL Akord of SCLEROSIS Amale Fibrosis diffhauta tubu Collapsing alomordopathy-morp vorint of FSGN epithelial cell hyperplasing POUR PROGNOSIS) collapse of glomerular tuft & o Idiopathic of HN ass. Both sJeroju & N-S areas show diffe effacement of foot precen at Podocytes of visceral epithelial cells of glomeruli E trapping of igM e complement in areas of hyalinosis MEMBRANOPROLIFERATNE CHistologicel pattern of immune mediaty, GLOMERULONEPHRITIS القدر (10-20%) Histologicalf choractrial by Thickening of glomerulos RM proliferation of mesangial cell Leucocyte Inkitration Efloloy 10 (Idiopathic) +Type- (Immuno-coreplay) +Type-2 (dense-deposit)→C3 2° (Along with systemic disease) MORPHOLOGY LIGHT MICROSCOPY • Glomeruli # -Large and hyperellular glomeruli Proliferation of nerangial cels) •Ina/reation of leuconfes. (Epithelial CRESCENTS •Accentuation of lobulos Architecture (prditentiarif mesongial cello Thickening of GBM (iegmental & capillory loops) Subontothelial immine complex-deposits - Forms new BMduplication of BM results in "Tram-Track appewang ↳ PAS or silver splits eflension of mesungid process int cell capilly loops Inf t sub endothelial immune complex deposition dep of mesagal matrix OTUBULES→ Vacuralation & droplets of hyvino ONTGRSITUMN mild chronic intl cells OBV normal, change in "hypertension" Lpleorm achvation by insmane complex C3 is dep Figh Seon in granfor pattem capils of loops Mesangocapillag glomerulonephrith sume nenaturin in non-nephroliz range. Combinel Nephrolic-nephritic pichire Some 50% Chronic AF prigrea int RPGN Matrixs