University:
Camosun College
Course:
NURS132 | Promoting Health and Wellbeing
Academic year:

2023
Views:

373

Pages:

3
Author:

Aysha A

GASTRIC APENOCARCINOMA Most commor Canle 90% Definition JH.isluri I consumption of dietor carcinogens Chronic H lylon Benzo porene/ I salt & smoking Food I preservatives H.Pylon carcinome ? How mucosal inflammation ← decreases secretion of Aid & Pepsin Favours Backrial growth continution of nflammation Mucosal Atrophy intestinal metaplasia dysplasia CARCINOMA RISK FACTORS Environmental •H.pylori infection • Nikites, reduced intake of groen Fruits & Vegetables. • Low Fat or protein consumptiom Rubber & Coal Workers Host Factors Chronic gastritis -Partical gastrectomy Burrets Besophagus II) Macroscopic growth pattern// Genetic Factors Famiy histy of gastric cap HNPCC syndome Li-Fraumeni syndrome drome Type-1 772-2 :solid tumor projects ints lumen as Peoploid or superficial Hat noduler mass lesion Shallow dag erosive crater// Resenble chronic Peptic uler//. lucose from, nodules Raised Morgies shaypal, irreguts,Beaded/ Base Necrotio, rassed!! PATHOGENESIS Familial gastric cancer Gerraline loss of functin mutations in me tumour. suppressor genes CPHI CPH, ~ Encodes the E-cadherin // MORPHOLOGY Sporadic Gastric concr Loss of E cadherin Dev of diffuse gastric concer -Mutationd THE // BAX (Apoptoins) COKINA Ccelly Loss of Foastia SITE Lesser curvature > Greater curvature o Pylorus & Antrum (~50%) •Cardie (as%) •Body & Fundes (15-25%) Cors of adhating 50% Abd- mucie signet-cell-crayf *Derth of Invasion Early gastric carcinoma Advanced gastric carcinoma PFUI Neoplasm, From submucosa wall// Limited to mecosa + submucose -wither without perigastric emph node Earf lesions Advanced lesions/ Bette prognosis posploid Fingering ulcerata * tourens Class Intestinal Gross-Polyploid Bully tumour, may or may not be ulurated/ Microscopy From gland like fubular shectures, Diffuse Gross infiltrate cleep) into Stomach without forming lesions. Desmoplasti Heaction flattening of Rugal folds thickening of wall →Cunon narrowed leathe Bottle apperance Linis plastica Arise in the areas of inte stinel meta plasia Tumour cells mucin va coules SPREA SPREAD OF CARCINOMA Locel Musuliserosa/ Invede duaden & Other Rethops, colon, Livr, Pancreas// Comphe tic vil submucosal & subsetaal lymphatics to both regional & distant lymph node Metastane to NODE VIRCHOW Cуарн :-clinical manifestation of ocult neoplasm (Troisns) Penumblical Lymph nodes subcutaneous called SISTER MARY NODUE • Krukenky tumor (oucher) CLINICAL FENNRES ) Arik from precunor lesions (flat dysplasia e adenomas) 2) Presents with satiety, bloating, distensin & Yornithing. GOC 1) Troisern sign Supraclewy Palpable comph node (Virchow's CN) 4) Troussen sige migrating thrombophlebitis & deep vein thrombosis... # Ab pain I weigh lots Hematemesis-Rare Trokers sign: Meckel Dilin 2 %. population, 2 feet-illareal vale, 2 mches lung, 2-maxM>F single-untimesestriz Bursery of Rowd The Blood ap Purtorat! Peptic ularatia + Blem