University:
Camosun College
Course:
NURS132 | Promoting Health and Wellbeing
Academic year:

2023
Views:

320

Pages:

4
Author:

Aysha A

MYCOBACTERIUM LEPROS Incubation 5-7 yrs GT-12-13 days obligate intracellular - di Fricut on culture medice • obligate aerobe • Mode of transmission = nasal droplet > contact > Breast milk. CLASSIFICATION Ridley Joplins Cel-median Inws low Lepramatou, leprosy. OBL Bodarline leprosy BB Boderline OBT Borderline tuberculoid - Tuberculoid leprosy dofazime DCR PR (Depsone Rifampicin) multibacillary Cole ways! Pausibacilleg...) BACILLARY LOAP Bacteriological Load highw 4-6+ 0-1+ mdex Skin lesions 444 Few, asymri ili Many, symmetrical leonine facies, Eyebrow & central clernya Alopecia Late Early cell-med. Normal irim Negative Lepromis test 107- ar anuloma Positive Marco $ CUIACHOW VIACHOW CELLS HSR Granuloma Epithelial. Nerve lesions PIAGNOSIS LAN SMEAR MICROSCOPY SPECIMEN:- 6 sampler smeer som -4 skin [Fure hand, choek, chin, Buttock] - Eer loke Blow :- Early morning Nasal mucosa. scraping :- muwcal scraper to scrupe nasal septum *SUT-SKW SMEAR Biopsy nodulor lesion, thicknet nerves Interpretation stain: In stain (5% H2504= Microscopy:- Calobi/cigar Bundle Fite Foracco stain) (Bundles of Bactria) AFB Virchow rell / Lepra cell/foamy cell. (Macrophages with leprae globi) Int 2 GRADING 1-10 Bacilli in loo fields 1+ 1-10 Baulli in lo fields→2+ 1-10 Bailli in Pr field 3+ 10-100 Bailli In perfield 4+ 10001000 Railli in parfield 5+ >1000 Baulli in for fint evey field 6+ Bactrim index Noof (+5) Scored in all smears N. of Smears X Morphological index:- of of SFGB out of total Bacilli Solid bagmentet granular Baulli MIBI X CANNOT BE GROWN ON CULTURE 3 (20°C to 6-9 months) O ANIMAL CULTIVATION. Footpad of mice Nine Bandel Armadil. • lo time sentilile than microsuja •Detect drey resistance & Evipotes of drys • Vairabbiliy of Bacilli Detect ELISA (19M) 6-9 months Antibody Detectia • Against pal-1 (phenolic glycolipide →F(A-ABS (Fluoresent-leprosy - Antibog) LEPROMIN TEST Absorption test 0.1mL of Lepromin antigen subdind cases 92% sensitive hiven Intradermal in Pream Hom 100% specific. Interpretatia > Fernandez Reaction (Early) titolo > lo mm induration Aftr 48 hours (2 days)하 > Mistuda Reactia (Late) > 5 mm Nodule afte 21 days (3 weeks) (600) one of complications LEPRA REACTION PB-6 12- MB PRUGS (100g) DAPSONE, RIFAMPICIN, CLOFAZIMINE (350) OS ICLARITHROMYCIN (WHO-Regimen) Type-1 Type-IN Hypersensity Ran Type-11 Type-III-HSR Erythema Nodusum I Usually seen in BB Downgrading (LL) Reversal/up-grading (TT) Seen in BL & LL Can be seen before or a fly treatment seen afto treatment (TINEL) Type-1 M/C Featare- Edema. M/c Nerve- Ulnar Nerve Type-2 Crops of Tenderr Inflammed Nodules (Duet Tnf Alpha) Th1 medial, by Th2. medinhd y Glucocorticoids Thalidomide. Clofazimine # Mycobad TB is diff from other myabacterienes 6 NIACIN # Immunomodulat vacille for Mj.tapa Mycobacbin Indicum 20 Pranii ↓ MW