Carcinomas of Lungs

SMALL CELL CARCINOMA - OAT CELL CARSINONA MORPHOLO GY High moligrat alts epithelial tumour with paroendocrins features + es 2:1 SITE Arise not ond in MAJOR BRONCHI) but also portion of lung in posipheral • Cuts section cofl, friable, and white, and shows extensive hemorshugs & Necrois LIGHT MICROSCOPY • Characteristics of Tumour cells: -size and shape- small found to fusiform. The small cell is termed as an oat celll. Diametr is less than 3x the diamets of small resting lympocyte. (25 mirons) - cytoplasm:- Scanty! ill-defined cell Boder. Nucleus :- Hypx chromatic - granules chromatin (salt & pepper pattern) Thudeer molding! - Necledus:- Absent or inconspicious. - Mitotic count:- High with an average of 60-70 milosis per to high power fields •Growth pattern- Tumour cell grow in sheets/ clesters. The stroma is delicate, Vascular, scanty. • Necrosis: common & Extensive EM: Tunerell shows membrane-bound beurosecrety grorules omgin: Nerraendocrine prognitor cell. Rehaviors High grade & most aggressive wids metatar. Nurable to sury & morky sarisiti & chen they LARGE CELL CARCINOMATO undiererentiated maligant apithelint tumout of lung Morphdogy. GROSS Artse more rep in pophagut lung. with welt-detained ordersy Forms spherical tumour Cutsection shows bulging, fleshy, homoginous, sarcomatous app MILROSCOPY Turmoir cells are large with moderate amount of cytoplasm, Iorge neleis prominest nucleolis & (vesicula) chromatin Vesicar neclei with proms pudel Lorge cells with abd-cytoplaen. CARCINOID TUMOUR Low grade malignant epithelial neoplam from neuroendocrine cells. ari u MORPHOLOGY ✓arilous Central or peripheral GROSS CENTRAL Anger or spherical polypoid masses in the Mainstem bronchi covered by intact. mucesa. small, I cm diametr. endo project inte Brunchiul lumen as bronchial lesion... COLLOR-BUTTON LESION PERIPHERAL- SOLID, NODUL AR MILRO SCOPY - or gonoid, trabeculur, palisading, Ribbon, or rovelle uniteroy, reguler, with uniter Round nuclei, find granuls ind cell, are unitolog! Lytoplasm-eusinphilic, moderat Typical (MD) lack macro sis EIMH dens core-granules Atspicel ine mitosis & focial incplemorphism narons. inc cellularits. chromatin (+) cerotonin, s.enols, Calik CLINICAL FEATURES A →50% Asymptomat. symp -persistent cough, hemoptysis va înlectio •ntraluminal growth, Emphysema Metustutis & sec of vaso active amines- Benign course 10./o produce CARCINOID SYNDROME intermitht attacks of Diarrhoes, Flushings Cyanosis CQUAMOUS CELL CARCINOMA Preneoplast lesions ocarm Bronchial epithelium and include squamous mustaplasia co dyapbasice, trans forms to carcinoma in sith MIRPHOLOGY most central sites & grown pattern - Tumorsorrise in purtia of lung, from majer bronchi GROSS -Peribranchial growth- fumon pop as ULCERATINE LESIONS in branch, penetrates wall of bronchus and ing. alg pribronchial thisve ne auf mediastinurn -Intra parenchymal growth Tumor gows like couliflower-like inkapar erthynel mass which pushes surr lung substance. Exophytic growth storts as endobronchial turmour projinto Lumen of bronchi producing intraluminal mass obstract bronchus - atelectasis- infection distalt obs. -Gray-whik coly & TiRM-HARD consists CUT SECTION Focal oreas of Hemorrhage or necrosis. Central NFCavit MICROSCOPY scoporatnizatia (Epithetal keratin pearls) Intrarelly bridges gps blu cells GRADES Sq. lays 2. Mod. diff (ind-cell keratinizatio) Eosinophilic, glassy, dense cytoplasm LEE only introallater bridges without foci of kuahuzhu. ADENOCARCINOMA Tumor 3 imu leord Aideriorin in site. (115) BRONCHIO ALVEOLAR CARCINOMA (BAC-obsolete) No skornal invasion MORPHOLOGY GROSS occurs in teminat hunchoalveolar regions of lungs. seen in paripheral portion of lung, as single nodule (Cain lesion) measuring zum or lase MICROSCOPY - Reve Bronchoulveals growth pattern with no evidence of Stromal, vascular or plural invasion. Grow along pre-existing alveolar walls without destruction of alveoler architechoc. (Lepidic) SUBTYPES Columne, pg-shapel or cuboidef Non-inecinds distinctive, tall, eylopluimin and intra-alun muu Mecinus - Mixed → macinas, timmung INVASIVE ADENOCARCINOMA Invasive malignant grilmelial tamon in which tumor cells. shows glandular diferentialia muan production. Nm-smotus danroute pathan lapidies aciner, papilly, solid, micropapillag du MORPHOLOGY 5.1758- mue empherall lovated, and smalle App- Irvmasses ranging from 2 to 5 cm in diamet Cut sector- Non-mucinus tumor turns grayistr white mucinous tumor app gelatinous (1) Auner - Ase glands line & Embolicaliutos (1) Papille i single cell luges. cou obravasily connective tissue core 10) micropapillag wosist of small pupils tufts of tumou cells without FV CTC //... Macin adonorarunomas consist of tall colunty cells with It Rain SATU THI TUMOUS Gross- (+) & Thwinal Trams taut (TF-1) solit STRENO nodule apicel mushyle Be but metaston wid