University:
Camosun College
Course:
NURS132 | Promoting Health and Wellbeing
Academic year:

2023
Views:

196

Pages:

3
Author:

Aysha A

CHRONIC MYELOGENOUS LEUKEMIA (MPN) one of Myelopridiferative neoplasm of Pluripotent Haematopoietic stem cell splenomegaly! & Lenkocytosis. clonal Hematoporti stem cell disorder Characterial by proliferation of one or more of myeloid Menge (E, G, M, Mastcel) Chimera fusion of BCR-ABLY gene + Philadelphia chromosome (90%) Philadelphia Chromosome Acquired chromosorne Abnormality in all proliferating hematopoietic Stem cells. (Erythroid, myeloid, monocytic медокороко) Balanced reciprocal translocation between long arm of chromosome of 9 &22; t (9,22) (934;q11.2). Increases the longth of chr. 94 & shortening of 22. SHORTENED CHROMOSOME OF is know as (22) PHILADELPHIA CHROMOSOME BCR BCR Chromosome 22 (Philadelphia) Chromosoma BX-1 Nonnal Chromasante 22 Lengthend Nirmal drornain BCR-ABL gene BCR-ABL ABC-1 gene Proencar of chromosome 9 joins BCR of chromosome-22. ABLI prot oncoga oncogene product Dev of CML Grogenic Addition CLINICAL FEATURES Age: 40-60 yers of age Sex-MSF onset. Insidiasis Symptoms Non-specific Fatigue, weakness Fallness of Abdomen clue to splenomegaly (Leukemic infiltration & extramedully hamedppoiesis Hepatomegas - Mild or modende (60-70% cases) PERIPHERAL BLOOD Hemoglobin Less than 11 g/dL PERIPHERAL SMEAR courien food misonin RBC Normocytic Norinochromic Arrania WBC -Morked Leucocytosis (12-600×109/L) Predominant cells - Neutrophilk & Myalocales Blasth ove Less than to % of WBC - Basophilic & Eosinophilia Plateleth- Mrombocytosid BONE MARROW Cellularis Morked hypercellular ME Ratio: 20:1 Erythropoiesis Diminished erythropoiesis Myelo poiesis Marked hyperplasia (<10%) Megakajoles 1↑↑ SEA BLUE INSTIOCYTES Hende Gaucher Cells uni And T Senin LDH ↑ Prognosis-Pour PHASES: CHRONIC, ACCELERATED, BLAST CHRONIC Mosty diagnosed in this phase 02-6 yrs > ACC or Blastic phase if not treat ACCELERATED PHASE More aggresive, last for few months omyaloblasts=10-19%. (Blood or BM) • STRIKING BASOPHILIA (20% or more) • Persistent THROMBOCYTOPENIA And • Megakaroto proliferation in sheets or cluster Increasing SPLENOME GALY BLAST PHASE No Aver Rirds Thamboogtopenia Bleeding episodes 20% Blok or more. Myeloblast (70%) or Lymphoblast (30%)