University:
Camosun College
Course:
NURS132 | Promoting Health and Wellbeing
Academic year:

2023
Views:

220

Pages:

4
Author:

Aysha A

RABIES Rhabdovinises 1000% Fatal disease // MORPHOLOGY Bullet shoppel (75nm in width, 180 nm in length) Enveloped (Have lipid envelope, spikes are embedded) - Nucleocaspid (Helical symmetry, single-stranded negative sense RNA, nucleoprotein & polymerase protein • Antigen Calycoprotein Ir & Nedeo Caspid) pattoguresi & in Vasion) GLYCOPROTEIN G D Envelope 2) Species-specific (Pathogenesis) 3) Binds to Acetylcholine" recepto and Induce neutralising antibody 4) Used in Hemagglutination inhibition test to detect anhbod in patients serum Role in immunits Induces pentralising Cantibodies which are protective vi nature. 6) Role in Vaccinettu (Subunit vaccine) NUCLEO PROTEIN Capsid proteins ass with Viral RNA Group-specific No role in binding and inducing antibody Antigen detection Rete dead in Patients serum by direct IF-test. Antibodies are not protectis Not used for Vaccinetta TRANSMISSION PATHO GENESIS 6) Disseminates bo Hippocampus and Cerebellum eye Brain Salviary. glande (5)Ascend upwards Quins binds receptor at acetylcholine NM3 SKELE TAL MUSCLE skin Spinal cord DORSAL ROUT GANGLION (4) Centripetal spread along motor Nerves (2) Replicates Locally (Muscle/Connective Tissue) DOW Transmitted to human, by the bite of infected dog. (or secrations) CLINICAL MANIFESTATIONS Incubation Period:-variable, prolonged (20-90 days) •Cherte in children than Adults (7) Centrifugal sprend alang nerves to (a) salivan (6)ayes glands (comer) (c) Skin thesence of Negri Bodies (ICEI) in the brain parenchyme Distance from inorulethor to CNS Bites on Head, Neck, Rupparlimbs •Shot People • severe lacerations Low Host Jimmunity PROPORMAL STAGE (2-10 days) Non-specific symptoms such as malaise, anorexia, nauser, fever, vomitting, photo phobia, sore throat. (Paresthesia, Pain, Pruritus) around the wound site. 2 Encephalitic (80%) ACUTE. NEUROLOGIC PHASE Paralytic (200%) Encephalitic rabies (2-7 days). Hyperexcitabilits (Anxies, Agitation, Bizzare-bonevins Lucid Interval (Period of hypvexcitabilif is topicely followed by complete lucidif that becomes shorter as disease progresses. AUTONOMIC DYSFUNCTION ↑ Lacrimation, ↑ salivation, ↑ perspiration - Hydrophobia (Fearof watx) Aerophobia(kerat Air) painful spasm of larysel, resping inlectek Bralaste Neuro Paralytic or Dumb Rabies (200%) Patients who are Portiall vaccinated or Bat Rabies Vines. Characteris Flaccid Puralysis, often begins in bitten lind and progressing to quadriparnesis with facial paralysis. #drophobia & other feet = Absent// 3 COMA & DEATH Follows acute neurological phase Come & Death within 14 days. Poralytic Rabies (30 days - survival) Death is certain. LAB DIAGNOSIS. Antigen detectly from hair follides art the hope of neck & corneal smear - by direct IF test ural isolation -Mouse Inoculation:- -cell lines Inoculation Mouse neuroblastoma & BHK Antiborly detection CSF Ab > Serum Ab Lap app. Early produced in Rabies infected individuals Y present afps vaccination Viral RNA detection By RT-PCR Negri-bodies-Retection intracytoplasmic eosinophilic Characterist basophilic inclusion with innur granules, composed of rabies vinus protein & Viral RNA/ Location: Purkinje cells of cerebellum & pyramidal neurons of hippocampus stains HR E. Steller stains Immunohistochemisty Peroxidase-labelled specific Abs, are uced to detect viral inclusions in formalin fixel tis sue.