University:
Camosun College
Course:
NURS132 | Promoting Health and Wellbeing
Academic year:

2023
Views:

38

Pages:

5
Author:

Aysha A

SYPHILIS Treponema palladiun Mode of transmission: Veneral syphilis sexual contad Non-Verval syphilis Blood transfusion, Direct contact Spread penetrates me skin through minuts abrasions on skin ve inucosa, within a few hours, entis Lymphaties to produce Mlection and metastatic foci long before the appesance of lesion. Blood is infectionat. Incubation period = 9-90 days (AV days of um organisms/.. 500-1000 PRIMARY SYPHILIS Primary change single painless hord indurated ulcer, covered by trick exudate rich in spirochetes. Common site- Penis (Male) Cervix (Female) Anal comal Rectum (Homosexudy mouth * Pagional (mouinal) Lymphadenopaty occurs within 1 week of skin lesions. Lyruph nodes - painless, firm, hon- suppuruhve, Bilateral * Chancre-hoals within 4-6 work, but lymphadenopathy porist. NON VENERAL MODE By direct contact ↳ Prinor chancre or fingers (Extra-genital) By BlNd transfusion No occurrence Secondary Syphilis Joun ofts 6-12 weeks after the healing of primary lesion skin and mucous membranes are affected" skin-Rashes (Palms & soles) * Condylomata lata (macocutaneous papules which Coalesce to form large-pink to grey lesions in worm moist inferisigginmous areas such as perianal region, vulva & scrotum) A Mucous Patches (superficial mucosal erosions) Generalized Lymphadenopathy. chanche persist in fl of cases. LATENT SYPHIUS Secondary syphilis usually subside within 2-6 weeks j. infection proceeds. characterised by the absence of clinical manifestations of syphiles with (+) sesobjilul tests for syphilis & nomd CSF Sindings . Eary (wimin first yer of mfection) * Latent syphils Late (abites First you of mfection) Persistent Lifelong infection. Fates Dev of Late syphilis (Rove) Spontaneous cure. LATE OR 3° Prozone Phenomenon. At time is high, Falsecti > sensis. Low m late stage. Treponemal or specific tests Specific Abs ar delected by using Pallidern Afs TPI (7. Palladium Immobilization test) - Use live actively mobile 7 pallidum, which become (immobilized after they combine with specific Abs FTA-ABS (Fluoresent Treponemal Antibo of Absorption Tes Patient serum is layered on slide which is prev coated with Killed. 7. pallidum. Fluorescent labelled Anti-Human Imminoglobulin is added, and then slide is examined unde fluorent microscopi. Hicht sensitive & specific in all stages of syphilis First-serologicel test to be (+) following infection IgM-FTA-ABS Test detects ont IgM antbodies. used to detect CSF Ab5. TPA (T.Palliden Agslahal ter TAHA C7-PalL Hemgh test TPPA (T. Pallich particle Hen test) PCR amplify. T. pallidum specific genes such as 47-KDa Surface Antigen important in congenital & neurosyphili 1