Chaples 1: Intro & Plasma Proteins

Bloodchaples 1Intro & Plasma proteinsBlood liq connective TillueAngadult -: S-G It i.e 8% of body weightBull coat - By contribugation anticoagulated tube.UsesPlasma(52-57-1.)deliction of abnormalityin L.E cells & atypicalsully coat (1%)cellsRedWBC & plabetdelection of bacteria jungi,cells (43-47-1)parasite etcFunctions of blood-:92% H2OWater homeostasis -: 55% of blood has PlassmaIn conditions of hypovolemia i.e like diarolia / Vomittingmuchare activated to water contin-1 of bloodOncotic pressure -:Albumin in blood exert osmotic pressure known as oncoticpressure that control cappillary filtration & preventsedema formationBlood Volume- -Serum-Total BV is 70-80ml/kg of body weightPlasma- - clotting factoruses.In adult male, 5-6ltTetal call serum is usedJemah, 4.5-5.5ltJor growth of human all.used invitroIn childrent,-Serotinin is in serumthe total B.V is 80-90ml 1kg.as it during clottingbut absolich volume is less.plablets release itconnect Plasma Protein 6-8g /100ml of Plasma.Albumin (4-s-sql.)Globulin (15-39%)Fibrinogenalbuminuria. it appearsin liver(0.3.1g)L,B,2formed byin urine if kidney diseaseplannais then .Antibodies are globin withoutPlaumapheresis. The extracorporealA:G = 1.7:1seperation of blood compone nts resulthelps in detecting prognosisinfiller choin Abnormal plasmaof some diseaseproteins are reperatid from whohbody by semipermeabh memb. Done marrow & Hemopoisis -B. .M. Examu -needle aspiration & bone marrow biopsy.Sternal puncture illac crest 2 Apinous process-Myeloid erthyrold Rationleucocyte erythrocyct3:11:700Hemopoisis1) mesoblastic1) Yolksatearly as 2nd week of gestation2) Non - YS - :they are Paraaortic esplancopleura (DSD) & aortagonadmesonuronB cell progenitor(AGM)pheropotentstem cell.2)Hepatic stageadamsbooldalmosta2ndtrimester of pregnancy In lives -ssphinstarts5th week2nd triguesterof gestat.rah of formis his than newor boo101.00/ pattiest'peak atit vy letter5th monthol112-8gestalcondom tube ofstops albirth3) Medullary - : In Bone marrowth month of fetal lifeintial only for granulocytic & megakaryocyticthat time arythro poetic in liver onlyenythropoesis in B.M toward ds end of 3rd trimestor18 thin continue the supportPat of MH6 Billion all per kg of bedin W / day in adult2.5 RBCplintedlocation2 IMD FlowCHART j Check sg: 62 gk Pal, table 8-2chartHemapolesisPg.63.Stem allsHemopoetic growth factorsProgenitor1) erythropoletin In tedneydue lop orthrough precursorIntermedial precursor cells2) Introbuikins - IL1 to IL11Mature cellsILseconophilsIL2&lymphocyteILI&IL23) CSF -monocyt & macroph.M monocyCSF-1 = macrophageG - granoLIF = control grouth of megakaryocyt &GM bothstroma alladoptimRBC (No nucle; mitochondria, Ribosome)Red all count -glucose metabolismIn adult male 94.5- 6 millionHMP(nd mm90% by EM10% by shunt.In as jemah 4.5-1.5In newborn6-8in child - 3-SPacked cell Volume -Hemocrit is the fractional volume of blood that erythrocytes occupy.provides red cell population useful info on red all manAdultmale46%(40-50)" female 42% (37-47)whenaredeformedasoccursincellsspherocytosisorsickleallmore,plasmaistrappedftwpackedall,gives falls high resultover ESRESR more rouhx formation /lawvisosity ,5 temp,didbiconcaryforthathighfibrinogenwillshape Boxdeficiency - hypochromic microcytic animiaVit B-12 & Folic acid- -Proteindeficiency cause hypochromic anemicReticulocyte Index -= Reliantough %XAct HetNormal HctHemoglobin & blood IndicesSynthesis of Hb -:emorpHeme is formed in mitochondriasucciny) - CAA + glycineGlobin is in ribosomes.PyrodixalphospheTypes of HbL-iamina B-latoadipicaciAdult HbL2B222ALA synthesFetal Hb (HbF) -:& amino- livulinicacidAt adult is 11HbAHbA2as fetal (TO-90 %)Porphobilinogen97%3%detected1month baby (23%)1st yearProtoporphyrin - IX8ththeweek intraof babyafterbirth slowlyHemoglobin bartssyn th. Ferrous iocHememinor 16 in letal lifeGlobineplace 46 toby 6monts Jullyin 'clous'! it has thalanemiafunctionHemoglotin1 cyriological aspectswhen fully naturated 1g of Hb carries 1.34 me of oxygen.MCV-MCV = Hemocrit (%) X10MCH = 46(9111) X10+RBC canRBC count in million/mm3normal value is 78 to 96 JL27-33 pgMCHC (%) = 46(g/100ml)X 100PCV/100ml33-379/dL