FerroptosisFERROPTOSIS00:10Iron dependent pathway of cell death by lipid metabolismTerm coined by DixonExcessive intracellular FeinduceReactive Oxygen Species(ROS)Exhausts GlutathioneAntioxidant mech.Unchecked Lipid PeroxidationMembrane dysfunctionComplete loss of Membrane Permeab.Necrosis like cell deathElectron Microscopic Findings- Loss of mitochondrial cristae- Mitochondrial outer membrane rupture-mitochondrial amorphous densitiesMECHANISM OF FERROPTOSIS05:00GPx Glutathione peroxidaseOxidises GSH DefemoxamineSLCBA2ErastinSLC7A1CysteineSulphasalazineFe3tFe3tCysGSHGPGSSHFe2tFerroptosisOOHOHROS(Peroxide) (Alcohol)LPCA73PUFA PE4PUFAVit E. FerrostatinConversion of Peroxide to Akchol prevents cell injuryCauses-Inhibition of GPx by RSL3 -RAS selective lethal small md.BPeroxideFIN! 56ROS-Inhibition of SLC3A2 by drugs like.erastinFerroptusisSulphasalazine- Inhibition of LCAT by Vit E & FerrostatinFerropturi- -Entry of iron inhibited by DeferoxamineIron supplements are not given in patient c inflammation