University:
Glendale Community College
Course:
BIO160 | Introduction to Human Anatomy and Physiology
Academic year:

2020
Views:

409

Pages:

3
Author:

Ray Payne

Section 19.3: The Proteostasis Network §Proteotoxic stress-related protein misfolding and other types of damage are a sever threat to cell function §Proteostasis Network monitors proteins from their synthesis, through folding, refolding, transport, and degradation §PN processes utilize molecular chaperones, stress response transcription factors, detoxifying enzymes and degradation processes Section 19.3: The Proteostasis Network §Heat shock response is the best understood stress response. §Works to protect an affected cell and its proteome by making rapid and global changes in gene expression that inhibit nonessential protein synthesis on ribosomes and increase the concentration of PN elements Section 19.3: The Proteostasis Network §Defective protein folding is responsible for a large number of human diseases §Examples include cystic fibrosis and CBS §Large number of protein folding disorders where there is chronic proteostasis dysfunction arising from adverse interactions between aggregated proteins and proteosomal components §Examples include Alzheimer’s, Parkinson’s, Huntington’s, and Type II Diabetes