University:
Glendale Community College
Course:
BIO160 | Introduction to Human Anatomy and Physiology
Academic year:

2022
Views:

161

Pages:

3
Author:

pakost5e

Section 8.3: Pentose Phosphate Pathway oxidation Glucose-6-phosphate dehydrogenase Alternate glucose metabolic pathway §Produces NADPH and ribose-5phosphate §Two phases in cytoplasm §Oxidative & non-oxidative hydrolysis Gluconolactonase §Oxidative 1. Glucose-6-phosphate to 6phospho-D-glucono-d-lactone § NADPH 2. 6-phospho-D-glucono-d-lactone to 6-phospho-D-gluconate Figure 8.15a The Pentose Phosphate Pathway (oxidative) Section 8.3: Pentose Phosphate Pathway §Oxidative – cont. decarboxylation 6-phosphogluconate dehydrogenase 3. 6-phospho-D-gluconate to 3-keto-6phospho-D-gluconate § NADPH 3-keto-6-phospho-D-gluconate to D-ribulose-5-phosphate § CO2 §Net yield - ribulose-5-phosphate; two NADPH §NADPH is a reducing agent used in anabolic processes Figure 8.15a The Pentose Phosphate Pathway (oxidative) Section 8.3: Pentose Phosphate Pathway §Nonoxidative §Produces intermediates for nucleotide biosynthesis and glycolysis §Ribose-5-phosphate §Glyceraldehyde-3-phosphate §Fructose-6-phosphate Figure 8.15b The Pentose Phosphate Pathway (nonoxidative)