Toxicity of N2O

University:
Indiana University South Bend
Course:
ANAT-A 210 | Human Anatomy
Academic year:

2024
Views:

354

Pages:

4
Author:

rifak9035

60Toxicity of N20:-is expands any are containing cavityIf given for>6hrsirreversibly oxedises.Cobatt atom of vit B12Inhibition of enzymesMethionine SynthetaseThymidalate SynthetaseBone marrow DepressionMegalobastic anaemiaPeripheral neuropathyPermilous anaemiaIt may beteratogenicFemaleanaesthetists tend to haverate ofIt trimester abortioncauses max. green house effect among anaetackagentschronic exposurespinal Degeneration. C/I of N20 -611> N20 expands any air containing cavity:CI1> venous are embolismoccurs m/cly in sitting pockerrforpost. fossa surgeriesN20embolussize.Most sensitive monitor to detect venous allembolumTrans ocrophagear Echo > Doppler > ETN2 >ETCO2 > CUP > Mill wheel murmue2> PneumotheraxN20the Size3> Lung cyst or bulle4> Intracranial Sxespecially post fossa SxPost. fossa is a bony space.So, N20pressure as vol. can't bePons & medulla can be affected 625> Pheumocephalus-N20 is C/I for 7 days6> Vitreoretinal Sx-- Vitreou fluid will come out duringSx.-To maintain of beth Ant. PostChamber surgeon puts bubble ofSF6Later vitreaus come backIf N2O is used it the size of bubblemaySurgeon opens it immediatelySudden dhompressionRetenal detailment7) TympanoplastyDue topressure, Graft gets dislodgedb) Acute Intestinal obstrucN20 causes further dilataten of loop.4) Pulmonary HTNN2O deffuses into endotracheal tube selfcuff pressure should be intermittentlymonitored. Conc" EFFECT :-63N20 is 35 temes more soluble in blood thanN2.blood verselN20repideabsorf." of N2D in bloodalvedeLVE conc" gradent inalvedimore absouph of N20Shoutening indue" time2nd GAS EFFECT :-:N20 also coni" of other inhalational agentthis way.Rapid Induc" of anaesthesia