10/25 Inoculation and Vaccination Smallpox Pathophysiology Epidemiology in the colonial era and 19th century Management: quarantine, treatment Inoculation Origins Methods Boston, 1721: smallpox inoculation controversy Individual decisions and public consequences Inoculation in the 18th century: variable implementation Inoculation and War Washington and the Continental Army Deliberate Infection, at Fort Pitt and elsewhere Vaccination Edward Jenner and James Phipps Success and controversy: vaccination riots, e.g. Boston 1901-1903 Smallpox eradication: 26 October 1977 The Challenge of Using Effective Treatments Effectively Failed eradication: measles, malaria, polio HIV: 2.5% of people with HIV currently received adequate treatment