University:
Rutgers University Newark
Course:
CHEM 335 | Organic Chemistry
Academic year:

2024
Views:

299

Pages:

44
Author:

Mahitab S.

Stranford Owen Punt. Jones 1 Kuby Immunology EIGHTH EDITION Lecture Slides CHAPTER 5 The Complement System Macmillan Learning 2023 The Complement System Complement describes a group of serum proteins that circulate in inactive form. Once the system is activated, there are multiple possible outcomes including: target cell membrane lysis, chemotaxis, opsonization to enhance phagocytosis, and inflammation. Macmillan Learning 2023 KILARS Fig. 5-1 The Alternative Tickover Pathway Small amounts of C3 are always being cleaved. Cleaved C3 is usually quickly inactivated if nothing is around for it to bind. Activated C3b binds to membrane of target cell. Factor B binds and is then cleaved by Factor D. C3bBb at the membrane is the C3 convertase. Properdin stabilizes the C3 convertase, which can then cleave many more C3 proteins. Newly active C3b binds to C3bBb to form C3bBbC3b, or the C5 convertase. Nuid-phase CT conversase (c) C5 convertase cleaves many C5 proteins. Macmillan Leaming 2023 Macmillan Leaming 2023 Facior B convertase → Cla Factor B Ch Factor D Factor D Csabb (3 comчные) Propendin (Factor P) Cb Cla CS convertare Fig. 5-8 Clb Cla Fluid-Phase and Membrane-Bound C3 Convertases (a) C3 (b) Fluid-pbase C3 convertase C3 C3h C3a C3(H2O) Factor B Factor B C3(H2O)B C3bB Factor D Factor D Ba Ba C3(H₂O)Bb Fluid-phase 3 convertase C3bBb Membrane-bound C3 convertase Fig. 5-8 Macmillan Learning Membrane-bound Cf concernse