A&P II Class: Blood

Blood 03/27 How physiology and anatomy whole blood affect the composition of does Definition n. Fluid the the RBC ? of connective tissue Specialized that cells are scattered in Matrix a Matrix · 1 Avid wh dissolved solutes (Ground substance) . · Functions s . Extracellular Protein Fibers 2 Transports (Collagen dissolved gases nutrients , , , Elastin hormones and metabolic , Waste Regulates body Regulates pH & · Composition temperature ion concentration Whole Blood Plasma Liquid (55%) Water · · · Majority (92 % ) Plasma Proteins (7 % ) Other solutes (smallest Amino Acids (AA) Glucose , Formed Elements (45 %) RBC majority 199 %) (Erythrocytes) · · · Plasma · WBC's (5) (Leukocytes) Platelets (Thrombocytes) Complex Proteins . Loose 3D Structure structure : Loose fun TYPES · Albumins · Osmotic Pressure Globulins The composition RBC by the of whole blood plasma being plasma proteins structure Formed element against foreign makes . proteins (B) affects the the liquid part of structure the determine the function . antibodies for blood The protection Of and > F 3 C S WB I Plasma . A . Water . Plasma Proteins B C Other . II Formed elements . A RBC's . B WBC's (5) . C . Platelets E J Y 1 HB B & Heme-Fe-O2 Heme-Fe-Oz Heme-Fe-02 1HB Heme-Fe-02 B 1HB & US J 1 HB . Subunit-Heme-Fe Subunit Amino Acids (Recycled blood) Heme-F2 into Heme Fe-Recycled = = 402 102/subunit Blood 03/27 Antibodies : · Attack Fibrinogen · Functions Remainder foreign proteins clotting in Circulating enzymes Red pigment Hemoglobin (carries O · RBC's · · = Trillions of RBC's 1/ of all cells Limited lifespan · Structure · Anaerobic metabolism = ATP Low energy demands · Only Cytoskeleton = Structure days removed/burst Anatomy & Physiology of RBC ~ · 120 Ana to · structure my outer-thicker Inner-thinner Physiology · · can form stacks that through narrow allows · Hemogloblin 1HB fast Heme Heme- Fe-Fe- Oz I 02 Heme-Heme- exchange · Each BF I flow of of O2 a max = Subunit - - smoothly blood vessels B 1HB bind L - , (fxn) 102 402 1 HB can bind max Blood 03/27 Oxyhemoglobin Fe bound Deoxyhemoglobin Fe only · : to : RBC Turnover Subject to great mechanical (Removal) · Hemolysis-burst (spleen · Macrophages Engulf : Fixed · live in Hemogloblin= O (bright red dark real stress pieces of RBC organelle(spleen) Protein (subunit-Hemz-Fe) V Subunit ! A A recycled ~ Heme-Fe Heme FCCY) B100g 03/27 The structure Hemoglobin of WBC's Heme-Fe-O . changes Adnormal the structure hemoglobin cell. Forgotten Questions RBC's causes . sickle J S 3 Homeocytoplast Young Stem cell) Myeloid (SC) Lymphoid (SC) Lymphocytes Megakaryotecytes Erythrocytes (RBC's) Leukocytes (WBC's) Platelets Neutrophil Monocyte 3F S Granular (-Phill Agranular (cyte) Basophil Monocyte Neutrophil Lymphcyte Eosinphil J EPO TPO From From body Release with low O2 levels Kidney Eosinophil Basophil Blood 04/03 How What Hemopoiesis does the pathway to Hemopoiesis Formation is affects the maintenence of and of homeostasis maintain - formed elements of bone in homeostasis ? RBC's ? marrow TYPES · Hemocyoblast Young cell : cell) . Lymp hoid - (stem stem cells Lymphocytes Myloid Stem cells RBC's (Erythrocytes) Megakaryotecytes Flake apart-platelets (cell fragments) : WBC's Basophil · Eosinphil Monocyte · Neutrophil Determined by Hormones chemicals Normoblast (Day 1) eject RBC Maturity. , Nuticulocyte · blood stream leave (1 RBC Erthropoiesis RBC need . · amino Glycoprotein travels to Red in acid , iron , . Homeopoiess . cells Lymphoid Platelets Epo Negative effects mitosis & increase which turns into Of levels (During anemia Feedback Lymphocytes. My loid , maintain low in the maintence of homeostasis develope either Lymphoid or (Megakaryotes) to by Hemoglobin synthesis (increase RBC EPO released hemocytoblast Enter blood BM (bone Marrow) production) · Vitamins Kidney & Liver Maintain homeostasis increase marrow into Hemoglobin Synthesis (Heme-Fe) Hormones (EPO) · Have nucleus Red bone day) (local Microenvironment in and WBC's RBC's . · turn RBC's into a by making Myloid stem RBC's , hormone called Blood 04/03 How affect homeostasis ."What homeostasis of WBC's ? does maintain WBC WBC's the is pathway to AA Leukocytes Have organelle Granus Types lack HB , "bags" are Granular · Neutrophils Eosinophils · Can leave Agranulars - Monocyte mphocyte Basophils & of blood by Capillary Amoeboid movement contraction positive chemotaxis High concentration = Used TYPESWCNewtroph of chemicals direction a of them Lots · as First cell & injury/infection Bloodstream= Highway Police - Find something Engulf (phagocytic Eosinophil · Rise = in numbers when Phagocytic-coated attacking wh antibodies (later in Cycle) Monocytes Becomes · Macrophage Aggressive phagocytic Lymphocytes · T cells , cells (Antibodies) , NK cells Bassamationlite finise one nutrients , (Leakier) & Release his to mines WBC's are organells capillary . either Granular Ephill , to move Agranular around (crowl) so waste (cyte) WBC's they . can leave have through Blood 04/03 pools (Heparin released prevent Thrombocyte-cell fragments (9-12 days) spleen reserves platelets · Platelets Can Clot if , local blood Clot · Functions Release of for clotting Production-Thrombocytopoiesis chemicals In Red BM · From TPO Megakaryotecyte in Kiney Microenvironment of Chemicals B100g OM103 RBC's · WBC's first need can to a nutrients move into of cite and the Hormones . blood RBC's the are nucleus Hemoglobin and injury . Forgoften · stream Questions made and by ejecting finishing Synthesis are the BLOOD 04/05 How does clotting P bases Describe phases , contribute events and , to homeostasis ? the last chemical reaction clotting a Phases Phases & Events) 1 . Vascular Chemical rxn · smooth Contraction of diameter" of vessel (hormones-Endothelial Y site Endothelium > - > Vascular muscle- = 2 Platelet . 2 spasm = ↓ cells) & size Sticky . · Z Fill 3 . traveling Plateletts Platelett opening s plug Coagulation Series of Chemical Thrombin Wall of a site & · rxns · in > - - - . Parrell > XS- Prod · bloodstream (outside) - News: Cat Vitamin , K , Vitamin a sticky site > formation > Release chem stuck get various & of encyme site protein clotting factore , 2 k In colic bacteria Foods Last Step CF I > - feedback Fibrinogen-Solvable protein Get stuck Throbin 2 , Fibrin (insolvable sticky plateletts (stronger) > Trap in - RBC's Clot retraction · Actin & Myosin Fibrinolysis pulling vessel wall together (Contraction Protein plasmin (enzymel breaks apart Fibrin prone to clots = Abnormal of blood · Medical When a pooling blood vessel breaks , a contraction of smooth muscles , cause the diameter of vessel at the site then make a sticky cite which catching plateletts to fill the gap and release chemicals. Site then Coagulation happens by both in and outside the , resolves . Phases of Hemostasis B100g 04/03 When vessel hole . clotting small a , with Then dissolve together , to , retraction make after with Forgotten Protein Needs: plasmin Ca2 clotting factors occurs to make the gets Fibrinogen Fibrinolysis with spasm sticky which catch platelets to fill Thrombin is made and occurs after and Coagulation reacts vascular Fibrin to "Pack" bringing Myelin the and Questions = Fibrinolysis Vitamin K various , protein it . vessels Actin .