Propranolol Cheat Sheet

University:
The University Of Western Ontario
Course:
MED 5161 | Principle of Medicine
Academic year:

2025
Views:

472

Pages:

2
Author:

Kyuwon J.

Propranolol ● Non-selective β-andrenegic blocker ○ β1 receptor blockage of heart ○ β2 receptor blockage ■ Lung ■ Vascular smooth tissues ■ Effect on bronchial smooth muscle ■ Metabolism impact ● Inhibition on sympathetic stimulation ○ With blockage of β1 multiple aspect will be decreased ■ Heart rate ● (-) chronotropic effect ■ Cardiac contractility ● (-) intropic effect ■ Cardiac output ■ Myocardial oxygen demand ○ Renal impact ■ Decrease in renin ● From kidney ■ Reduction of activation of renin-angiotensin-aldosterone system ● RAAS ● Cause to lower the bp ● CNS ○ Propranolol = liquid-soluble ■ Able to cross BBB ● ● ● ● ● ● ■ Able to affect CNS ● Anxiety reduction ● Migraine prevention Reduction in heart rate Reduction in cardiac output Lower blood pressure Myocardial O2 demand is lowered Decreased renin secretion Decreased tremor Cx ● Cardiovascular ○ Hypertension ○ Angina pectoris ○ Arrhythmias ■ Supraventricular tachycardia ○ Post-myocardial infarction ● Neurological ○ Migraine prophylaxis ○ Essential tremor ● Endocrine ○ Hyperthyroidism and Thyroid storm ■ Reduction of sympathetic symptoms ■ Decreased in peripheral conversions ● T4 →T3 ● Psychiatric ○ Performance anxiety ○ Stage fright ● Other ○ Portal hypertension ○ Infantile hemangiomas Propranolol Non-selective migraine, anxiety Metoprolol β₁ selective common for HTN Atenolol β₁ selective long acting Carvedilol β + α₁ heart failure Labetalol β+α hypertensive emergencies