University:
University of North Carolina at Chapel Hill
Course:
NURS 312 | Pharmacology
Academic year:

2020
Views:

499

Pages:

1
Author:

do3ran7ut

1.3 – “Neo “Neolithic lithic antineoplastics antineoplastics”: ”: cladribine, ccytarabine, ytarabine, gemcitab gemcitabine ine • All are phosphorylated to triphosphate form, which can incorporate into DNA → breaks or blockage of synthesis & repair by blocking DNApol-α & DNApol-β (cracked replication fork demonstrating gene flow out of Africa; cracked glass). Cell cycle specific for S-phase (Stone phase) • All share the same limiting toxicity: Myelosuppression & pancytopenia → immunosuppression (broken bone spilling marrow; immunocompromised cane) • Cladribine (clad in bearskins) o Cytotoxic purine analog (purine-shaped club) o Resistant to adenosine deaminase → ↑↑ intracellular levels. o Indications ▪ Hairy cell leukemia (hairy caveman) ▪ CLL, NHL • Cytarabine (saber-toothed tiger) o Cytotoxic pyrimidine analog (hexagonal patterned fur) o Only active against hematologic malignancies, e.g. AML, non-Hodgkin lymphoma (scratched out antibody archers, crab, & Tcell swordsman) • Gemcitabine (gems inside geode) o Cytotoxic pyrimidine analog (hexagonal patterned fur) o Active against both hematologic malignancies and solid tumors (tumorous rocks, with crab not scratched out)