University:
University of North Carolina at Chapel Hill
Course:
NURS 312 | Pharmacology
Academic year:

2020
Views:

358

Pages:

1
Author:

Accinkiquicpqw

6.2 – “The C Council ouncil of Elfavir”: NNRTI TIss (Nevirapine, ef efavirenz, avirenz, delav delavirdine) irdine) • Non-nucleoside RT inhibitors. Do not need intracellular phosphorylated for activation. (Outside Camelot, so not knights of the round table; Ⓟ knight riding away toward Camelot) Bind directly to HIV RT resulting in allosteric inhibition, preventing viral synthesis of DNA polymerase activity (spell book blocked directly by arrow cleaving DNA bookmark) • Adverse effects o May have Life threatening hepatic failure within 6 weeks of starting therapy. Abrupt onset flu-like symptoms, abdominal pain, jaundice, fever (stag with yellow glow and liver shaped spot) o Teratogens (massive spider & pregnant lady) o Numerous drug-drug interactions d/t induction of CYP450 system (functional buggy with CYP450 plates). Both efavirenz & delavirdine activate & inhibit system, as well as broken down by it; nevirapine less activating. o Skin rash; Stevens-Johnson syndrome-TEN (orc with tengu mask) • Efavirenz (Elf Queen) o Principle adverse effects unique to efavirenz are all CNS. Include dizziness, drowsiness, headache, psychosis, insomnia, nightmares (queen clutching head; gazing at trippy antlers; dark night). • Delavirdine (Princess Delavir) o Not an NRTI despite the suffix!