Do Not Cross Linezolid | Study Guide - Edubirdie

University:
University of North Carolina at Chapel Hill
Course:
NURS 312 | Pharmacology
Academic year:

2020
Views:

356

Pages:

1
Author:

Carissa Thomas

2.5 – “Do Not Cross”: Line Linezolid zolid • Linezolid (Police line) • Binds 50S ribosomal subunit, preventing formation of initiation complex. Bacteriostatic (jammed typewriter) • Active against G+ including staph, strep, enterococcus (purple jewels in clusters & chains) o Treatment of serious G+ infections including nosocomial skin & soft tissue infections and PNA and VRE (lung shaped uniform on nurse; resisting arrest in police van; purple diplococcus drums) o MRSA coverage (“No Mercy” pharaoh sarcophagus) • Adverse effects o Thrombocytopenia (broken plates) o Prolonged courses have reported optic neuropathy (cut optic nerve camera wires) o Peripheral neuropathy, usually in glove & stocking sensory impairment (detective gear) o Weak inhibitor of MAO, so may lead to serotonin syndrome (smiley face)

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