University:
University of North Carolina at Chapel Hill
Course:
NURS 312 | Pharmacology
Academic year:

2020
Views:

50

Pages:

1
Author:

Accinkiquicpqw

1.2 – “The Staphy Staphylococci lococci Strike Back”: Nafc Nafcillin, illin, oxac oxacillin, illin, dicloxa dicloxacillin cillin • Nafcillin, oxacillin, & dicloxacillin are narrow-spectrum β-lactams of the penicillin class (β lactam planet). Indicated to treat methicillin-sensitive staphylococcus. • MOA: Bind PBPs and halt peptidoglycan synthesis. • Extended activity against β-lactamase-producing bacteria, as bulky R-groups prevent β-lactamase binding (bulked up rebel fighters are protected from plasmid-ring β-lactamase guns) • Narrow spectrum against staph (purple coccoid space station). Drug of choice for methicillin sensitive, penicillin resistant staph (even though methicillin isn’t used clinically anymore). Nafcillin & oxacillin for staph (pencil-shaped staff; ox horns) • Indications: o Mild to moderate localized staphylococcal infections when given orally. Given empirically for skin & soft tissue infections, e.g. folliculitis, abscesses (Red ox hump). o Given IV for systemic staph infection, e.g. staph endocarditis (tricuspid pyramids) & osteomyelitis (fish skeletons) • MRSA (merciless pharaoh): produces PBPs with low affinity for binding β-lactam drugs. This renders β-lactams ineffective (altered wall builders who continue wall synthesis with protective gear, despite rebel missiles)