University:
University of North Carolina at Chapel Hill
Course:
NURS 312 | Pharmacology
Academic year:

2020
Views:

65

Pages:

1
Author:

ilikemyicons0y5

1.2 – “Hunchbac “Hunchbackk of Notre DNA”: Azath Azathioprine, ioprine, 6-MP, myc mycophenolate ophenolate mofe mofetil til • nucleosides consist of nitrogenous base, ribose, phosphate groups. Purine synthesis begins with phosphoribosyl pyrophosphate (PRPP) (synthesis continues! Pentagon pedestal being built with 3 P-shaped hammers). Metabolized to inosine monophosphate (IMP) (gargoyle imp), which is metabolized to AMP and GMP by separate pathways (gold gramps & grump statues respectively with purine haloes; “Pure As Gold”) Purine analog analogss • Azathioprine (AZA) & 6-mercaptopurine (6-MP) (Aza-merelda with purine earrings; captured gypsy) o AZA is converted to 6-MP, which must be activated by hypoxanthine-guanine phosphoribosyl transferase (HGPRT) (high priest activated captive). Blocks synthesis of IMP (knocking over gargoyle imp) → halting DNA & RNA synthesis o Cell cycle specific for S-phase (dilapidated stairs) o Indications ▪ Hematologic malignancy (cracked cancer crab, antibody archers, and T-cell knights in rose window) ▪ Chronic inflammatory conditions, d/t immunosuppressive effects (torn antibody lantern). Include treatment of graft rejection, SLE, autoimmune hemolytic anemia, inflammatory myopathies, IBD (inflamed colonic haustra lanterns) ▪ Disease modifying anti-rheumatic drug (DMARDs) (joint lantern with inflammatory candle). Not as effective as MTX; usually used in refractory disease. o Adverse effects ▪ Myelosuppression & pancytopenia → immunosuppression (empty bone serving tray; immunocompromised cane on statue) ▪ Pancreatitis (pancreas sponge) ▪ Hepatotoxicity (both direct and d/t reactivation of latent infectious hepatitis) (liver spots) ▪ Inhibition of XO → increased 6-MP levels. Risk of adverse effects hugely increased with allopurinol or febustate coadministration (allopurinol nuns with purine beads) • Mycophenolate mofetil (Quasi-mofetil) o IMP dehydrogenase inhibitor, blocking GMP synthesis (knocking over grump statue) o Powerful anti-lymphoproliferative drug. Used in a variety of inflammatory and lymphoproliferative disorders (torn antibody lantern) o Adverse effects ▪ GI distress is common (queasy Quasimodo) ▪ Myelosuppression & pancytopenia → immunosuppression (empty bone serving tray; immunocompromised cane on statue)