University:
University of North Carolina at Chapel Hill
Course:
NURS 312 | Pharmacology
Academic year:

2020
Views:

170

Pages:

1
Author:

Alma Stephenson

4.3 – “Murder on the Metro Expre Express” ss” • Metronidazole (metro) • Bacteroides fragilis. Coverage of polymicrobial anaerobic infection, as e.g. in intraabdominal infection (man stabbed in stomach). Also has activity against some protozoa. • MOA: Forms toxic free-radical metabolites that disrupt bacterial DNA; bactericidal (oxidized DNA-shaped rails) • Clinical indications (clindamycin above the diaphragm, metronidazole below) o Activity against Entamoeba histolytica. Intestinal protozoa → dysentery, liver abscess (Do not enter sign from entamoeba sketch). o Giardia (protozoan shield) o Trichomonas: treats vaginitis & cervicitis with strawberry cervix (magician with hat & strawberry) ▪ STD. Given to both patient and partner (couple in the back) ▪ Wet mount test to inspect for trichomonas (“does the alibi hold water?”) o Gardnerella caused vaginosis (Ms. Gardner with Venus fly trap) o Substitute for amoxicillin for H. pylori treatment in penicillin allergy (helicopter outside) o Activity against anaerobic bacteria including (gas masks) ▪ Bacteroides, Prevotella, Fusobacterium, Clostridium ▪ C-diff pseudomembranous colitis (chocolate fountain) • Concurrent ingestion of alcohol during metronidazole treatment (oral or vaginal administration) causes a disulfiram-like reaction, with flushing, tachycardia, palpitations, N/V (hip flask with XXX) • CYP450 inhibitor (cars yield to trains)