University:
University of North Carolina at Chapel Hill
Course:
NURS 312 | Pharmacology
Academic year:

2020
Views:

496

Pages:

1
Author:

5prinzg1s

7.1 – “Insert Cytocoin to Co Continue”: ntinue”: Interfer Interferon on α, IFN-β, IFN-γ • Interferons are host cytokines than produce antiviral, immunomodulating, & antiproliferative effects. Released by infected cells → intracellular signals activating immune response (virus infected manager is spreading cyto-coins). Upregulation of INF synthesis in infected cells accomplished by interleukins (Luke enabling activating kiddos). • Clinical uses of IFN-α (pachyderm man) o Interferon α treats hep B & C infections (hippo). Given as injections. Pegylated INF allows longer half-life and steadier concentrations, requiring less frequent dosing. o Approved for treatment of many neoplasms ▪ Hairy cell leukemia (hairy creatures) ▪ Malignant melanoma (melatonin ghost) ▪ Kaposi’s sarcoma by HHV-8 (Kate’s posies on cabinet and in maze) ▪ Renal cell carcinoma (crab in kidney shaped claw machine) o Condyloma acuminatum caused by HPV (pill bug jar) o Has many adverse effects (why we want new Hep C treatments!) ▪ Flu like syndrome with headaches, fevers, malaise, myalgias within 6h after dosing (fevered kid). In as much as 30% of patients after initiating therapy. Generally resolves. ▪ Neuropsychiatric complications with chronic treatment, including tinnitus, retinopathy, confusion, psych disturbances, profound fatigue (sick kid) • Depression resulting from INFα treatment can be profound and may include suicidal ideation. Contraindicated in severely depressed or suicidal patients. ▪ Pneumonitis, interstitial fibrosis ▪ Myelosuppression (maze is bone-shaped and red cell dots are being eaten). Important to consider when giving other myelosuppressive agents. ▪ Metabolic complications, including thyroid dysfunction, low-grade fever ▪ Dermatologic complications, e.g. alopecia ▪ Rarely, drug induced lupus (plush wolf in claw machine) • Interferon β (β Invaders) o Approved for use in relapsing type MS (“Combat lesions though Time & Space”) • Interferon γ (Gammaga game) o Treats CGD. May activate macrophage otherwise unable to form oxygen species needed for oxidative burst (bursting asteroids)