University:
University of North Carolina at Chapel Hill
Course:
NURS 312 | Pharmacology
Academic year:

2021
Views:

167

Pages:

4
Author:

Hallie Randolph

Modified release tablets (MR): The drug release from an oral medication follows three main mechanisms: 1) Immediate(IR) 2) delayed (DR) 3) extended (ER).  Both ER and DR systems are referred to as (MR) dosage forms. Schematic illustration of the percentage of drug released from the different modes of drug delivery, including immediate, extended, and delayed drug release. Remington, the science and practice of pharmacy. IR Tablets: The tablet disintegrates quickly in the stomach fluids which releases the drug to provide rapid onset of therapeutic effect following dissolution and absorption in the gastrointestinal tract. DR Tablets: *These release the drug at a time later than immediately after administration (i.e. there is a significant lag time between a patient taking a medicine and the drug releasing from the dosage form). *Site-specific targeting is a type of delayed release which aims to target specific regions of the gastrointestinal tract, e.g. the small intestine or colon. ER Tablets: The drug is slowly released over an extended timeframe. Modified-release drug delivery: It refers to the modification of drug release from a solid oral dosage form (e.g. tablet, pellet or capsule) with the aim of delivering drugs at: 1. desired rates; 2. predefined time points; or 3. specific sites in the gastrointestinal tract. Tablet Ingredients API, active pharmaceutica l ingredient Excipients (Inert materials) Tablets Excipients may be classified according to the part they play in the finished tablet : They aid in the tableting process and ensure that tablets of specified quality are prepared : diluents binders, disintegrants , glidants and lubricants. Affect the performance of a tablets, including bioavailability and stability and give desirable physical characteristics to the finished tablet: coatings, antioxidants, matrix formers (release modifiers), colorants, flavoring agents and sweeteners