University:
West Coast University
Course:
NURS 180 | Pharmacology
Academic year:

2021
Views:

471

Pages:

1
Author:

Carissa Thomas

DRUG NAME: Toradol (ketorolac tromethamine) Drug Class: NSAID (non-steroidal anti-inflammatory) Indications/Therapeutic Effect: short term management of moderate to severe pain MOA: Inhibits prostaglandin synthesis, producing peripherally mediated analgesia. Has antiinflammatory and antipyretic properties. Metabolized by liver, excreted by kidneys. Adverse Effects: headache, nausea, diaphoresis, increased liver enzymes, GI bleeding, injection site pain, increase in serum creatinine Significant Drug-Drug (or Drug-Food) Interactions: Use with anticoagulants and NSAIDS may increase the risk of bleeding. Toradol may diminish the diuretic effects of loop diuretics & loop diuretics may increase the nephrotoxic effects of Toradol. Avoid use of other NSAIDs concurrently with Toradol. May decrease effectiveness of diuretics, antihypertensives May increase serum lithium levels Increased risk of nephrotoxicity with cyclosporine Contraindications: Advanced liver disease, advanced renal disease, active or recent GI bleeding or peptic ulcer disease, previous history of allergy to other NSAIDs. Consider OTC or herbal supplements that also increase bleeding (garlic, fish oil…) Nursing Considerations: Monitor urine output (withhold drug if less than 225 ml of urine output in previous 8 hours), monitor serum creatinine. Assess for hypersensitivity in patients with asthma. Assess pain. Confirm safe dose. Confirm patient allergies. Pregnancy Category: C Patient Education: Dosing, side effects, avoid use or use caution with alcohol or CNS depressants and aspirin, NSAIDS or other OTC without consulting with a healthcare provider. DO not continue use if rash develops. References: Lexicomp Database, LHMC, Davis’ Drug Guide