3b. Breast Cancer (Leiva)

Thanks for the Mammories -Brand/Generic : Letrazole (Femara) -CDR416 Anastrazole Cuprelide Grazoline Arimidex) Lopron) ! Coladex) T Tamoxifen DDI Abem-daily other 2 : 21 palbo & Ribo on 7 off Palbo-metastic & DiarrheaOnly other 2 : early ? late Staye HR +: CDR413 HER-2 +: Need to HER-2 No : have + +x invasive/Non-invasive HR + 3 HER-2 +: Need Combo tokno need ② ③ operable - · Eligible us for non-operable surgery Neo-adjuvant is · ( then surgery then adjuvant 3 chemo ER/PE +: pre-meno (HR ) @ Tamox + I Ovarian ↳ don't have to add - If clotting · or Supression on more VTE risk give : , A 1 + ovarian X GNRHA : Lupron . watch drugs supression out Boneesity! Zoladex Al Myalgia /Arthralgia DLT : xygen ? : Worst SIE Armidex/Femara switch to tamoxifen endometrial hyperplasia Tamoxifen & Al both-hepatotoxic - * , a rish invTE but know diff monitoring for SERM Als tamoxifen is . much more common US ⑪ Hot Flashes : ↓ SX use oxybutynin DDI : tamoxifen wh SSRI Fluotexine of paroxetine cymbalta Menopause for pre-meno & deepen for menop. post-menc ⑤ Loading Dose : Faslodex ! - - ⑥ screening : transwomen > Luminal A ! - got (Hormone Driven) yu St yr on hormonal therapy need Mammogram or MRI & ⑦ look & graph : efficacy vs . ⑧ Matching "Ciclibs" Need screening ! of Caplin- (DK416 drug ? combo curve toxicities ) Neutropenia (Myelosupp . Palbo-severe Aben-Diarrhey-start lopramide -SkinRxn (SSS) Riyo-QT prolongation w/ Tamoxifen after 1stcouple - loose stools happens in 1stmonth ⑨ Sequencing of ↳ TX : Do not ① Chemo [DO & Radiation TX] NOT Start Endocrine 1 Endocrine TX ③ Endocrine TX - Injection Drug : site xn wh Fulvestrant MoA Major if WI toxicities needs to be given additional med (A) + Lupron)