ExamNow #1

Question 1 Which of the following statements is trum regarding development of breast cancer? A Puberty induces terminal differentiation of lobules in the breasts BBreast density increases with age and is highest in older women C After menopause, most of the breast tissue contains lobule type 4 D Higher amount of fat in the breast makes mammogram difficult to read E The amount of glandular tissue in the breast is the highest during lactation Answer is E Question 2 The tail of the breast tissue extends all the way to the, and into the axilla T True F False Submit Answer is True Question 3 Which of the following are the mechanisms by which anthracyclines exert their anticancer effects? A Anttvacyclines contain a planar ring structure that helps them intercalate the DNA B Anthracyclines can inhibit topoisomerase II causing double strand breaks in the DNA C. Antivacyclines generate superoxide free radicals through tron dependent reactions D All of the above are mechanisms of anticancer action for anthracyclines Submit Answer is D Question 4 Anthracyclines, A May not be administered above a maximum lifetime cumulative dose B Are safely given with trastuzumab C Dose limiting toxicity is motor neuropathy DAre used for HER2 positive disease only Submit She didn't go over this one Question 6 Match the following drug classes and their mechanism of action: A. Anthracyclines B. Alkylating agents C. Vinca alkaloids D. Antimetabolites E. Topoisonerase inhibitors F. Taxanes Instructions Only 1 mechanism/drug class. Please enter only the alphabet corresponding to the repair mechanism. Do NOT write the entire class name Mechantem of anticancer action Form reactive comic ermecate that they quart Cause extensive payment of mertubes lending to formation of microtubule asters Antenate in the Chill and cause double mandr 1 Alkylating agents 2 Taxanes 3 Anthracyclines Drug Class 2 Submit Answer B, F, A Question 7 Match the following drug namen and the mechantsof A Adriamycin Cyclophosphamide C. Vinblastine D. Methotrexate E Camptothoc Abnpane Olymachamame/drug clans. Please enter only the alphabet correspondeng to the nерия теститат Do NOT write the anpow clar name A Answer is B, F, A Quest Each of the lowing a known side effects of the anthracyclines A-green secretons depending on the agent used C Carthyopathy D. Morreuropathies Answer is D Q2 Anthracyclines A May not be admistaredove maxanum latime cumulation doss Are safely given with trastuzumab Coeng oxicity is motor neuropathy Are used for HERZ postive deesse only Answer is A Questi Dezzoxane serves as a restar agent for anthracyclines it two ways. They ar A Prevention of cardiotoxicity and treatment of extravasation Protection of healthy ouls from cytotoxic effects and treatment of plasma leves C Emergency treatment of overdose and prevention of cardiotoxicity Treatment of extravasation and preventing bladder toxictly Answer is A Question & The primary types of adjuvant cytotoxic chemotherapy regimeris for the treatment of breast cancer include all of the following, EXCEPT A Taxane containing regimens Anthracycline containing regimens Trastuzumab containing regimens D Selective Estrogen Receptor Modulators Submit Answer is D Question 5 Which of the following hormonal agents should NOT be used without ovarian suppression in an ER+/PR+ premenopausal breast cancer patient? A Tamoxifen Anastrazole C Toremifene D Leuprolide Rubmit Answer is B Question & Which of the following is a consequence of the estrogen agonist effects of the SERMis (selective estrogen receptor modulators? A Hot flashes B Increased incidence of endometrial cancer C Arthits D Osteoporosis Subnet Answer is B Question In 2010, Di Leo ef al published following results of clinical trai (CONFIRM trial that compared efficacy of fulvestrant 500 mg versus the then approved dose of 250 mg. Based on the results of this study fulvestrant's indicated dose was increased to 500 mg. This was due to significantly improved PFS with fulvestrant 500 mg (HR8, 45% 0.68-094, p=0.000) Based on the subgroup analysts shown below, do you agree thuat all patients will benefit from thes incresssed dose of 500 img 106 A Agree al subgroups favor fulvestrant 500 mg significantly Disagras not all subgroups favor fulvestrant 500 mg significanty Answer is B Question & 2010. Di Leo ef al published following results of clinical (CONFIRM trial that compared efficacy of fulvestrant 500 mg versus the then approved dose of 250 mg. Based on the results of the sturly, fulvestrants indicated dose was increased to 150 mg. This was due to significantly improved PPS with fulvestrant 500 mg (HR-08 95%CI 0.88094-000) Based on the swibgmus analysis shown below, do you agree that patteries whis showed pour response to pror endocrine therapy wilt heeft hom this used dose of 500 mg 300 130 12 A Disagree most patients receive grunat benet havestan 500 mg significantly compared to the ongina dose of 250 mg Agree patients who showed poor response to prior endocrine therapy will benefit more from the increased dose of 500 mg Answer is B 842-Active Learning Wik 9 (Wed-in Class) Question 9 COK 4/6 inhibitors such as nhocidi specifically target the BRCA 1 and 2 mutations ansen in breast canc T: True FF Answer is False Question 10 Which of the following describes abemaciclibi and its place in therapy? Asa COK 45 inhibitor used along with endocrine therapy for treatment of metastatic breast cancer #CDK4 inhibitor used for triple negative breast cancer CARnitor used for BRCA 1/2 mutation posive breast cancer Disa SERM used to treatment HR negative premenopausal patients Answer is A