University:
Amherst College
Course:
BIOL 330 | Biochemical Principles of Life at the Molecular Level
Academic year:

2010
Views:

286

Pages:

16
Author:

Ashlee Terry

Chemical Biology 03 BLOOD Biomolecular Structure IV. Nucleic Acids Chemical Biology 03 BLOOD Biomolecular Structure IV. Nucleic Acids 9/21/09 Fundamental Pieces of a Nucleotide Organic Chemical Groups What fundamental Groups Are there in a NUCLEIC ACID? Organic Chemical Groups NUCLEIC ACIDS Building Block of DNA: Nucleotide DNA: deoxyribonucleicacid Where is the deoxy? Where is the nucleic base? Where is the acid? Building Block of DNA: Nucleotide DNA: deoxyribonucleicacid Where is the deoxy? Where is the nucleic base? Where is the acid? 5’ 3’ 5’ 3’ What is the phospohodiester bond? The purine and pyrimidine bases How do base pairs interact with one another? AT Watson-Crick Base Pair GC Watson-Crick Base Pair How do base pairs interact with one another? Weak Hydrogen Bonds (2 kcal/mole) AT Watson-Crick Base Pair AT has two H bonds GC Watson-Crick Base Pair GC has three H bonds 5’ 3’ 5’ 3’ How do you put together a DNA duplex? DNA double Helix • A, G, T, C are the four nucleic acid bases upon which all of our inheritance is based. • A on one strand H-bond with T on the other • G on one strand H-bond with C on the other • The Bases project off of a sugar phosphate backbone. How do base pairs interact with one another? ATmajor: NhOme ATminor: N O GCmajor: NOh GCminor: NhO What Does a Protein “See” in DS DNA? • “Reading” the major and minor groove – Grooves are lined by sequence specific Hbonding groups – Major Groove deep (8.5 Å) & wide ( 11.5 Å) • • • • GC CG AT TA NOh hON NhO OhN – Minor Groove (7.5 Å) & narrow (4.5 Å) • • • • GC CG AT TA NhO OhN N O O N What nucleic acid bases do you find in RNA? Adenine Guanine Cytosine Uracil

Chemical Biology 03 2010 Gene Regulation

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