University:
Amherst College
Course:
BIOL 330 | Biochemical Principles of Life at the Molecular Level
Academic year:

2011
Views:

275

Pages:

17
Author:

bymncouby7jn

BioChem 330 -‐ Course Outline • Metabolism and Bioenerge1cs (II) – ENZYME CATALYSIS: • kineAc constants kcat, Km • CatalyAc strategies, the serine proteases – CATABOLISM (breakdown) • Carbohydrates – – – – Glycolysis Tricarboxylic Acid Cycle Electron Transport Chemiosmosis and ATPase • FaQy acids and amino acids Fa7y Acid Biosynthesis Reac1ons in Cytoplasm Figure 20-26 Figure 20-30 Figure 20-31 AMPK Fuel Gauge for Cell AMP  AMPK ACC  AMP dependent protein kinase ATP AMPK ACC  Figure 20-31 part 1 Prostaglandins are made from faQy acids in response to infecAon or trauma Figure 20-36 Cyclo-‐oxygenase (COX) Inhibitors prevent formaAon of Prostaglandin and relieve pain and fever Nonspeciﬁc Page 719 Speciﬁc for COX-‐2 Biosynthesis of Cholesterol p721-‐729 Page 721 Biosynthesis of Cholesterol Four steps from HMG-‐ CoA to the isopenentenyl pyrophosphate – step 1 is most highly regulated Figure 20-37 Biosynthesis of Cholesterol Part 2 Three steps from the isopentenyl pyrophosphate – to squalene Check out all the isoprene units in squalene! Figure 20-38 Squalene is set up for CyclizaAon in the next Step Figure 20-39 Here’s the Magical CyclizaAon Step Figure 20-39 Shedding some –CH3 and oxidizing those carbons and reducing others converts lanosterol to cholesterol Page 724 Cholesterol can direct protein synthesis by inducing transloca1on of ac1vator precursors from the ER to the Golgi Figure 20-41 Figure 20-43 Cholesterol lowering drugs such as these prevent heart disease by inhibi1ng HMG-‐CoA reductase Figure 20-42 Diseases of Cholesterol Transport Figure 20-44

BioChem 330 - Course Outline Fatty Acids and Amino Acids

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