University:
Binghamton University
Course:
BIOL 313 | Cellular Neurobiology
Academic year:

2024
Views:

313

Pages:

1
Author:

CrystalMintah

To inactivate the neurotransmitter 1.) Specific enzymes for specific neurotransmitters 2.) - AChE for Ach 2nd messenger system uses phospholypase C and Pip2 - used by GABA and serotonin along others 1.) Neurotransmitter binds to a receptor and a g protein is activated 2.) G protein activates a molecule of phospholipase C and phospholipase c acts on a molecule of Pip 2 which is present in the bound of the membrane 3.) Pip2 4.) Pip2 breaks into the lipid-soluble DAG and the water-soluble iP3 ER- Storage of calcium ions 5.) iP3 diffuses through the cystoplasm where it goes to the endoplasmic reticulum and makes it releases stored Ca2+ 6.) Meanwhile, the DAG in the membrane acts on protein kinase C 7.) Protein kinase C uses energy to phosphorylate with the help of the calcium that was just released from the endoplasmic reticulum to be activated 8.) Protein kinase C with ATP for energy phosphorylates an ion channel to open/ close/ change the state of the ion channel Meanwhile, the CA2+ that was released from the ER can also be used to activate …….. STORYTIME ! Some nerve agents. Like Sorin and Norvichok act by binding up AcHE. So Ach does not get broken down at the synapse. Antidotes are looking to fijdmolceules that can pry the nurse agent off the AChE. Nerve agents have a time window during when you can do thi - later and binding is permanent, so knowing time course of the nerve agent , you can try to get the antidote in before binding is permanent.