Education Attenuates the Effect of Medial Temporal Lobe Atrophy on Cognitive Function in Alzheimer’s Disease. The MIRAGE Study (Table) - Edubirdie

University:
Boston University
Course:
GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management
Academic year:

2022
Views:

440

Pages:

3
Author:

Rhianna Osborne

Table 1. Description of the patient sample Variable Value N 270 Age [years] * 75.23 (8.83) Men : women 109 : 161 Duration of disease [years] * 5.49 (4.42) Caucasian : African-American : Asian-American 193 : 41 : 27 Educational level, high : low 166 : 104 MMSE score * 17.38 (5.86) MTA * 2.59 (1.19) APOE ε4 (+) : ε4 (-) 160 : 110 CVD rating * 24.46 (24.95) Head circumference [cm] 55.99 (2.67) * mean (SD); MTA: medial temporal lobe atrophy; CVD: cerebrovascular disease; MMSE: Mini-Mental-State Examination; APOE: apolipoprotein E Table 2. Linear regression models examining the relation of MTA and education to global cognitive function Model 1 Model 2 Model terms β (SE) P β (SE) P MTA -1.54 (0.41) <0.001 -0.75 (0.56) 0.18 Education 0.82 (0.88) 0.35 4.86 (2.13) 0.02 Age -0.12 (0.06) 0.03 -0.13 (0.05) 0.02 Education x MTA NA NA -1.57 (0.74) 0.03 Model 1 included separate terms for education and MTA to assess their independent contribution to global cognitive function, and Model 2 added an interaction term between education and MTA to determine whether education modified the relation of atrophy to level of cognitive function. Ethnicity and variables with a putative effect on cognition such as age, education, gender, head circumference, apoE genotype, and CVD rating were included in both models (only significant predictors are shown). β indicates the estimated effect and SE the respective standard error in the multiple regression analysis. Negative β represent an inverse interaction between the predictor and cognition performance, whereas positive β point to a positive interaction. NA: not applicable Figure 1. Normal P-P Plot of regression standardized residuals (dependent variable: MMSE)

Related Documents

Education Attenuates the Effect of Medial Temporal Lobe Atrophy on Cognitive Function in Alzheimer’s Disease. The MIRAGE Study (Table)

Education Attenuates the Effect of Medial Temporal Lobe Atrophy on Cognitive Function in Alzheimer’s Disease. The MIRAGE Study (Table) - Page 1

Education Attenuates the Effect of Medial Temporal Lobe Atrophy on Cognitive Function in Alzheimer’s Disease. The MIRAGE Study (Table) - Page 2

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