University:
Brigham Young University
Course:
CHEM 489 | Structural Biochemistry
Academic year:

2023
Views:

95

Pages:

3
Author:

NebulaNomad99

Oxidation of Polycontratterated fatty acidg Poly cunsaturated Cantaring more than one Fatty dosible acidit bonds. Eg:-18c Linoleate-C-D, Cu-A" Cortfiguration. Linoleate Linoleryl-CoA Linoleoyl-CoA undergoes 3 Passes of B-Onidation Sequence to jould 3 molecules of acetyl-CoA & the Cof estere of a 120 Casaturated Fatty acced with a Cu-A³, Cu-D Configuration. This intermediate cannot be used by the enzyme of the B-Oxidation pathway. Its doceble bands are in the Cis Position. However, the Combined action of enoyl-CoA Isomerase & 2.4-dienoys Cof reductase allows reentrs B. Caldatleextry of the intermediate into the B-Oxidation parkway. This intermediate degraded by 5 B-Omidation passes to yiend 6 molecules of acetyl CoA. 18 12 9 Lensleyot C-09, C-02 B. Oxidation (3 cycles) Acetyl CoA 3 43,02 enoyl-Caff S-COA Cin-13, C06 12 Banlidation (one Cycle & 1st sxidation of 2nd eyele Acetyl-Cof 5 2 14 S-COR 2,4-dienoys Cog trans-12, Cu eductase 3 10 trans 1 enoyl-CoA 'S-CoA (taans D³) Boxidation 5 Acetyl-Coq (Oxidation of a Polyunsaturated fatty acid) Oxidation requires a 2nd auxillary enzyme in addition to enoyl-Cof isomerase: NADPH dependent 2.4-dienoyl Cof reductase. The Combined action of these 2 enzymes Convert a trans 1 Cis-14-dienoyl-Cof intermediate to the trans-gt-enayl COA Substrate necess necessary for B-oxidation The Overase result 'id Convention of l'enoleate to 9 molecules of acetyl-CoA. Complete Omidation of odd-number fatty acids Fatty acids with an odd no. off Canbong are Common in the lipids of many plants & Some marine organims. Cattle & other reunikant arinaly Yann Laege form amments (CH3-CH2-Cao-ducing tenmental of 04 3c Propionate Cacbohydrates in the rumen. > The propinate absorbed into the blood by the livee & other tissues. saidis Small quantities of Propionaje e ane added as a mold Inhibitor to some breads & Coreats thur entening the human diet. The long chain add no. fatty acids are oxidized in the Dathway like even chain. But the end Products are acetyl-CoA (20) & Praptonyl-CoA (30) The Acetyl-CoA enters to TCA Cycle. The Propionyl-CoA enters Involving 3 enzymes. a different Pathaway